caa a22 4500 465790194 CHVBK 20180323112021.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00177264 doi (NATIONALLICENCE)springer-10.1007/BF00177264 Ifosfamide and mesna in combination with other cytostatic drugs in the treatment of patients with advanced cancer [Elektronische Daten] [Geoffrey Falkson, Martin Chasen, Hendrè Falkson] Summary: Fifty patients with histologically confirmed advanced malignancies were treated with ifosfamide and mesna plus other cytostatics. The other cytostatic drugs added to the treatment regimen were cisplatin (36 pts), etoposide (31 pts) and doxorubicin (20 pts). Among previously untreated patients objective response was documented in 12 of 19 pts with ovarian cancer, 9 of 14 with small cell cancer of the lung and in all 3 pts with Ewing's sarcoma. Among patients with disease refractory to prior cytostatic treatment, objective response was documented in 8 of 9 with testicular cancer, 1 of 3 with high grade lymphoma and 0 of 2 with osteosarcoma. Side-effects due to the combination of ifosfamide plus mesna and other cytostatics were acceptable. No life-threatening or lethal toxicities occurred. Most commonly encountered toxicities were leukopenia (64%), nausea and vomiting (84%), alopecia (63%), CNS toxicity (30%) and renal toxicity (12%). Kluwer Academic Publishers, 1990 ifosfamide/mesna in combination advanced cancer nationallicence Falkson Geoffrey Department of Medical Oncology, University of Pretoria, Pretoria, South Africa aut Chasen Martin Department of Medical Oncology, University of Pretoria, Pretoria, South Africa aut Falkson Hendrè Department of Medical Oncology, University of Pretoria, Pretoria, South Africa aut Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 215-219 0167-6997 8:2<215 1990 8 10637 https://doi.org/10.1007/BF00177264 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177264 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Falkson Geoffrey Department of Medical Oncology, University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- Chasen Martin Department of Medical Oncology, University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- Falkson Hendrè Department of Medical Oncology, University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 215-219 0167-6997 8:2<215 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer