caa a22 4500 465790208 CHVBK 20180323112021.0 cr unu---uuuuu 170327e19900501xx s 000 0 eng 10.1007/BF00177247 doi (NATIONALLICENCE)springer-10.1007/BF00177247 Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines [Elektronische Daten] [Justin Cohen, H. Robins] Summary: Diethyldithiocarbamate (DDTC) and other dithiocarbamates are currently receiving attention as potential adjuncts to traditional chemotherapy. In vitro studies with rodent cancer cell lines have consistently shown that DDTC concentrations of 0.1-1.0μ g/ml are highly cytotoxic. Paradoxically, however, concentrations of 10-100 μg/ml have been significantly less toxic. In the present study, such a ‘biphasic' pattern was reproduced when 3 rodent cell lines were exposed for 1 hour to 0.001 to 1000 μg DDTC/ml. In contrast, in 7 human cell lines survival decreased steadily with increasing DDTC concentration (in the same dose range) without evidence of a biphasic pattern. These data might have implications for studies in which rodent cell lines are used to model the effects of dithiocarbamates in human tissues. Kluwer Academic Publishers, 1990 diethyldithiocarbamate nationallicence disulfiram nationallicence cytotoxicity nationallicence human nationallicence cancer nationallicence Cohen Justin University of Wisconsin Clinical Cancer Center, 53792, Madison, WI, USA aut Robins H. University of Wisconsin Clinical Cancer Center, 53792, Madison, WI, USA aut Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 137-142 0167-6997 8:2<137 1990 8 10637 https://doi.org/10.1007/BF00177247 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00177247 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen Justin University of Wisconsin Clinical Cancer Center, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Robins H. University of Wisconsin Clinical Cancer Center, 53792, Madison, WI, USA aut NATIONALLICENCE 773 0- Investigational New Drugs Kluwer Academic Publishers 8/2(1990-05-01), 137-142 0167-6997 8:2<137 1990 8 10637 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer