caa a22 4500 465794114 CHVBK 20180323112033.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02482607 doi (NATIONALLICENCE)springer-10.1007/BF02482607 Penn John Cullen Eye Institute, Baylor College of Medicine, 77030, Houston, TX, USA aut Oxygen-induced retinopathy in the rat: Possible contribution of peroxidation reactions [Elektronische Daten] [John Penn] Albino rats were maintained in 60% atmospheric oxygen from birth through 14 days of age. Age-matched controls were simultaneously raised in room air. Some rats were perfused with India ink before sacrifice and retinal dissection in order to study the effect of oxygen-rearing on the retinal vasculature. By this method it was found that oxygen-reared animals sustained a 36% loss of retinal blood vessels. Other animals' retinas were removed immediately after sacrifice and examined for evidence of lipid peroxidation by one of three means: 1) a determination of the presence of products of lipid peroxidation, 2) a measure of the loss of polyunsaturated fatty acids, and 3) a determination of retinal vitamin E level. Each of these determinations indicated that peroxidation reactions had occurred in the retinas of oxygenreared rats. Retinal vitamin E was supplemented in the young rats through the diet of the mothers. This treatment resulted in a two-fold increase of retinal vitamin E over levels in pups of mothers fed rat chow. Oxygen-reared vitamin E-supplemented rats sustained significantly less obliteration of blood vessels than non-supplemented oxygen-reared animals. Kluwer Academic Publishers, 1990 malondialdehyde nationallicence oxygen-induced retinopathy nationallicence peroxidation nationallicence polyunsaturated fatty acid nationallicence rat nationallicence vitamin E nationallicence Documenta Ophthalmologica Kluwer Academic Publishers 74/3(1990-03-01), 179-186 0012-4486 74:3<179 1990 74 10633 https://doi.org/10.1007/BF02482607 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02482607 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Penn John Cullen Eye Institute, Baylor College of Medicine, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 74/3(1990-03-01), 179-186 0012-4486 74:3<179 1990 74 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer