caa a22 4500 465794122 CHVBK 20180323112033.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02482608 doi (NATIONALLICENCE)springer-10.1007/BF02482608 Garner Alec Department of Pathology, Institute of Ophthalmology, University of London, 17/25 Cayton Street, EC1V 9AT, London, UK aut The role of hyperoxia in the aetiology of retinopathy of prematurity [Elektronische Daten] [Alec Garner] Oxygen in excess is toxic to living tissues and a capacity to neutralise its harmful potential is a requirement for survival. Experimental and circumstantial clinical evidence suggests that the requisite protective mechanisms are insufficiently advanced in the retinal vasculature of the premature neonate, such that babies of very low birth weight are vulnerable to even minor hyperoxia. Sustained hyperoxia produces degenerative effects on the developing endothelium with the result that the newest vessels at the retinal periphery are obliterated. Factors other than the level of inspired oxygen per se may serve to increase the risk of retinopathy by raising the rate of delivery of hyperoxygenated blood. Kluwer Academic Publishers, 1990 retinopathy of prematurity nationallicence hyperoxia nationallicence Documenta Ophthalmologica Kluwer Academic Publishers 74/3(1990-03-01), 187-193 0012-4486 74:3<187 1990 74 10633 https://doi.org/10.1007/BF02482608 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02482608 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Garner Alec Department of Pathology, Institute of Ophthalmology, University of London, 17/25 Cayton Street, EC1V 9AT, London, UK aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 74/3(1990-03-01), 187-193 0012-4486 74:3<187 1990 74 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer