caa a22 4500 465794149 CHVBK 20180323112033.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02482615 doi (NATIONALLICENCE)springer-10.1007/BF02482615 Palmer Earl Department of Ophthalmology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, OR, USA aut Results of U.S. randomized clinical trial of cryotherapy for ROP (CRYO-ROP) [Elektronische Daten] [Earl Palmer] Twenty-three centers collaborated in this prospectively designed study involving infants born weighing less than 1251 grams. Patient examinations began 4 to 6 weeks from birth. For entry into the study, two investigators had to agree that an eye had developed stage 3 ROP involving a threshold number of at least 5 contiguous or 8 total clock hour sectors of zone 1 or 2, and ‘plus' disease to a degree specified by a standard photograph. Cryotherapy was lightly applied to the avascular zone between the ridge of ROP and the ora serrata, in an average of about 50 separate spots. Outcome was determined 3 and 12 months following randomization, by means of masked readings of fundus photographs. Preliminary results were published in the Archives of Ophthalmology, Vol. 106, pp. 471-479, 1988. In these results from 172 of the 291 study patients, 43.0% of the control eyes had an adverse outcome (defined as retinal detachment, macular fold, or retrolental mass), as compared to 21.8% adverse outcome for eyes that received cryotherapy. Kluwer Academic Publishers, 1990 retinopathy of prematurity nationallicence clinical trial nationallicence cryotherapy nationallicence prematurity nationallicence randomized trial nationallicence ROP : retinopathy of prematurity nationallicence CRYO-ROP : multicenter trial of cryotherapy for retinopathy of prematurity nationallicence Documenta Ophthalmologica Kluwer Academic Publishers 74/3(1990-03-01), 245-251 0012-4486 74:3<245 1990 74 10633 https://doi.org/10.1007/BF02482615 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02482615 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Palmer Earl Department of Ophthalmology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, OR, USA aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 74/3(1990-03-01), 245-251 0012-4486 74:3<245 1990 74 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer