caa a22 4500 465794173 CHVBK 20180323112033.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF00145813 doi (NATIONALLICENCE)springer-10.1007/BF00145813 Effect of light on oxygen-induced retinopathy in the rat model [Elektronische Daten] Light and OIR in the rat [Benedetto Ricci, Domenico Lepore, Mario Iossa, Alessandro Santo, Mario D'urso, Nicola Maggiano] The purpose of this study was to establish whether exposure to intense lighting favors the development or aggravates experimental oxygen-induced retinopathy in the new-born rat. Five groups of Wistar rats were studied. The control group was maintained for the first 14 days of life under conditions of cyclical (12L∶12D) lighting at 12 Lx in room air. Two other groups were subjected, for the same amount of time, to semi-darkness (2 Lx; 12L∶12D), one with room air and the other with supplemental 80% oxygen. The final two groups were exposed to the same room air and hyperoxic treatments under intense lighting conditions (600 Lx; 12L∶12D). After the treatment period, four rats were randomly chosen from each group, sacrificed and their retinas examined under electron microscope. Marked structural changes were seen only in the photoreceptor outer segments of those rats exposed to intense light. In eighty-five of the remaining rats retinal vascular morphology was examined in retinal flat mounts after intracardiac injection of India ink. Retinopathy was observed in rats treated with hyperoxia but no significant differences could be attributed to the light conditions under which the retinopathic rats had been maintained. In the rest of the rats, axonal transport along the optical pathways was evaluated after intravitreal injection of (3H) taurine. In the two groups exposed to hyperoxia, axonal transport was altered, but less markedly in those exposed to intense lighting than in those exposed to semi-darnkess. Intense illumination under conditions of normoxia favors axonal transport. Exposure to intense lighting does not seem to aggravate oxygen induced retinopathy in the rat though it does produce structural lesions of the photoreceptors. Kluwer Academic Publishers, 1990 axonal transport nationallicence light nationallicence oxygen nationallicence oxygen-induced retinopathy nationallicence retina nationallicence retinopathy of prematurity nationallicence OIR : oxygen-induced retinopathy nationallicence ROP : retinopathy of prematurity nationallicence Ricci Benedetto Department of Ophthalmology, Catholic University, Rome, Italy aut Lepore Domenico Department of Ophthalmology, Catholic University, Rome, Italy aut Iossa Mario Department of Ophthalmology, Catholic University, Rome, Italy aut Santo Alessandro Department of Ophthalmology, Catholic University, Rome, Italy aut D'urso Mario Department of Ophthalmology, Catholic University, Rome, Italy aut Maggiano Nicola Department of Pathology, Catholic University, Rome, Italy aut Documenta Ophthalmologica Kluwer Academic Publishers 74/4(1990-04-01), 287-301 0012-4486 74:4<287 1990 74 10633 https://doi.org/10.1007/BF00145813 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00145813 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ricci Benedetto Department of Ophthalmology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Lepore Domenico Department of Ophthalmology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Iossa Mario Department of Ophthalmology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Santo Alessandro Department of Ophthalmology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- D'urso Mario Department of Ophthalmology, Catholic University, Rome, Italy aut NATIONALLICENCE 700 1- Maggiano Nicola Department of Pathology, Catholic University, Rome, Italy aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 74/4(1990-04-01), 287-301 0012-4486 74:4<287 1990 74 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer