caa a22 4500 465794440 CHVBK 20180323112033.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF00164835 doi (NATIONALLICENCE)springer-10.1007/BF00164835 Laboratory tests in uveitis [Elektronische Daten] New developments in the analysis of local antibody production [A. Kijlstra, G. Van Den Horn, L. Luyendijk, G. Baarsma, C. Schweitzer, M. Zaal, Z. Timmerman, M. Beintema, A. Rothova] Analysis of local intraocular antibody production is a valuable tool with which to confirm a suspected clinical diagnosis in uveitis. We have analysed paired serum and aqueous samples for the presence of specific antibodies against toxoplasma, cytomegalovirus, herpes simplex virus and varicella zoster virus. Of the patients retrospectively diagnosed as having toxoplasma chorioretinitis 75% had a positive antibody coefficient indicating specific antibody production in the eye. Local antibody production in the eye directed against CMV confirmed the suspected diagnosis of CMV retinitis in 50% of the AIDS patients investigated. So far we have not been able to demonstrate local antibody production against herpes simplex virus (26 samples tested). Two of three patients with acute retinal necrosis had a positive antibody coefficient against varicella zoster virus. Both of these patients had an even higher titer in the aqueous than in serum. Since the choice of therapy, in infectious uveitis, depends on the causative organisms, it is very important to confirm a suspected clinical diagnosis by means of aqueous humor analysis. Kluwer Academic Publishers, 1990 Aqueous humor nationallicence toxoplasma nationallicence cytomegalovirus nationallicence varicella zoster virus nationallicence herpes simplex virus nationallicence uveitis nationallicence diagnostic test nationallicence Kijlstra A. The Netherlands Ophthalmic Research Institute, The Netherlands aut Van Den Horn G. Dept. Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands aut Luyendijk L. The Netherlands Ophthalmic Research Institute, The Netherlands aut Baarsma G. Dept. Ophthalmology, University of Rotterdam, Rotterdam, The Netherlands aut Schweitzer C. Dept. Ophthalmology, University of Leiden, Leiden, The Netherlands aut Zaal M. Dept. Ophthalmology, Free University of Amsterdam, Amsterdam, The Netherlands aut Timmerman Z. Dept. Ophthalmology, University of Groningen, Groningen, The Netherlands aut Beintema M. Dept. Ophthalmology, University of Maastricht, Maastricht, The Netherlands aut Rothova A. The Netherlands Ophthalmic Research Institute, The Netherlands aut Documenta Ophthalmologica Kluwer Academic Publishers 75/3-4(1990-10-01), 225-231 0012-4486 75:3-4<225 1990 75 10633 https://doi.org/10.1007/BF00164835 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00164835 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kijlstra A. The Netherlands Ophthalmic Research Institute, The Netherlands aut NATIONALLICENCE 700 1- Van Den Horn G. Dept. Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Luyendijk L. The Netherlands Ophthalmic Research Institute, The Netherlands aut NATIONALLICENCE 700 1- Baarsma G. Dept. Ophthalmology, University of Rotterdam, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Schweitzer C. Dept. Ophthalmology, University of Leiden, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Zaal M. Dept. Ophthalmology, Free University of Amsterdam, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Timmerman Z. Dept. Ophthalmology, University of Groningen, Groningen, The Netherlands aut NATIONALLICENCE 700 1- Beintema M. Dept. Ophthalmology, University of Maastricht, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Rothova A. The Netherlands Ophthalmic Research Institute, The Netherlands aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 75/3-4(1990-10-01), 225-231 0012-4486 75:3-4<225 1990 75 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer