caa a22 4500 465794718 CHVBK 20180323112034.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00142597 doi (NATIONALLICENCE)springer-10.1007/BF00142597 Rod and cone contribution to adaptation processes in cat retinal ganglion cells [Elektronische Daten] [E. Günther, E. Zrenner] Extracellular ganglion cell responses were recorded to investigate mechanisms of light adaptation. Monochromatic test spots (575 nm) were projected onto the receptive field center of off-center cells and superimposed on a steady blue-green Ganzfeld background (Schott Filter BG 28), the strength of which was increased in steps of 0.5 log units to adapt rods. Response vs. log intensity functions were determined over a range of 7 log units of test light irradiance at each background level. At higher adaptation levels response thresholds followed the typical Weber function. Surprisingly at lower adaptation levels the sensitivity of the cell increased by about 0.7 log units, most markedly in a range of 1 log unit of moderate light adaptation when the background was changed from dark to the dimmest detectable background (10−5lm/m2). In the dark-adapted state a small off-response of long latency (40-100ms at 102 quanta · s−1 · μm−2) is observed at low rod stimulating test light irradiances. A transition to a cone-dominated transient response of 2 to 5 ms duration occurred at high intensities (105 quanta · s−1 · μm2). At mesopic levels the two responses seem to cancel each other, rendering a delayed off-response that is probably the result of rod-cone interaction. As in psychophysics, saturation can be observed at very high background intensities (106 quanta · s−1 μm−2). These data suggest interactions between rods and cones that determine the sensitivity of cat retinal ganglion cells at low levels of adaptation for suprathreshold stimuli. Kluwer Academic Publishers, 1990 adaptation nationallicence cat nationallicence rod nationallicence cone nationallicence extracellular recording nationallicence ganglion cell nationallicence rod-cone interaction nationallicence sensitization nationallicence Günther E. Dept. of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, 12, Tübingen, Schleichstr., Germany aut Zrenner E. Dept. of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, 12, Tübingen, Schleichstr., Germany aut Documenta Ophthalmologica Kluwer Academic Publishers 75/1(1990-08-01), 83-95 0012-4486 75:1<83 1990 75 10633 https://doi.org/10.1007/BF00142597 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00142597 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Günther E. Dept. of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, 12, Tübingen, Schleichstr., Germany aut NATIONALLICENCE 700 1- Zrenner E. Dept. of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital, 12, Tübingen, Schleichstr., Germany aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 75/1(1990-08-01), 83-95 0012-4486 75:1<83 1990 75 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer