caa a22 4500 465794742 CHVBK 20180323112034.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00146551 doi (NATIONALLICENCE)springer-10.1007/BF00146551 Central fiber contribution to W-shaped visual evoked potentials in patients with optic neuritis [Elektronische Daten] [Jelka Brecelj, Martin Štrucl, Marko Hawlina] We studied W-shaped waveforms that occurred in full-field responses to pattern large-field stimulation in patients who had optic neuritis. Affected eyes showed no absolute scotomata; visual acuity was normal at the time of recording. To evaluate the contribution of macular- and paramacular-derived components to the development of the W-shaped waveforms in the patients, half-field and central full-field stimulation was used. The responses were compared with those obtained with the use of experimental scotomata in healthy subjects. The W-shaped waveforms recorded in the patients closely resembled the responses observed in healthy subjects after the introduction of experimental scotomata. In all affected eyes, half-field stimulation showed absence of the ipsilateral P100 component or its interaction with the P135 component. Enhanced paramacular N105 and P135 components were seen over the contralateral hemisphere. Responses to central full-field stimulation were an attenuated and prolonged P100 in the majority of affected eyes. Results of our study showed that W-shaped waveforms in response to large full-field stimulation may reflect impaired function of macular fibers. These electrophysiologic findings, however, were not always associated with evidence of a central field defect demonstrated by Friedmann perimetry. Kluwer Academic Publishers, 1990 pattern reversal VEP nationallicence full-field W-shaped waveforms nationallicence optic neuritis nationallicence Brecelj Jelka University Institute of Clinical Neurophysiology, University Medical Centre, Ljubljana, Yugoslavia aut Štrucl Martin Institute of Physiology, Medical School, University of Ljubljana, 61105, Ljubljana, Yugoslavia aut Hawlina Marko Department of Ophthalmology, University Medical Centre, 61105, Ljubljana, Yugoslavia aut Documenta Ophthalmologica Kluwer Academic Publishers 75/2(1990-09-01), 155-163 0012-4486 75:2<155 1990 75 10633 https://doi.org/10.1007/BF00146551 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00146551 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brecelj Jelka University Institute of Clinical Neurophysiology, University Medical Centre, Ljubljana, Yugoslavia aut NATIONALLICENCE 700 1- Štrucl Martin Institute of Physiology, Medical School, University of Ljubljana, 61105, Ljubljana, Yugoslavia aut NATIONALLICENCE 700 1- Hawlina Marko Department of Ophthalmology, University Medical Centre, 61105, Ljubljana, Yugoslavia aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 75/2(1990-09-01), 155-163 0012-4486 75:2<155 1990 75 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer