caa a22 4500 465794777 CHVBK 20180323112034.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00146548 doi (NATIONALLICENCE)springer-10.1007/BF00146548 The effect of 2-amino-4-phosphonobutyric acid on the oscillatory potentials of the electroretinogram [Elektronische Daten] [Pierre Guité, Pierre Lachapelle] Previous reports have shown that an intravitreal injection of 2-amino-4-phosphonobutyric acid, a glutamate analogue that selectively blocks the photoreceptors' input to the on-bipolar cells, produces a rapid decrease in the amplitude of the electroretinographic b-wave. To our knowledge, the effect of this glutamate analogue has not been examined on the oscillatory potentials. We therefore conducted such a study. A needle electrode was inserted into the anterior chamber of the eyes of seven anesthetized and paralyzed rabbits to record simultaneously the electroretinogram and the oscillatory potentials. These responses were evoked by flashes of white light delivered in mesopic conditions. As expected, an injection of 2-amino-4-phosphonobutyric acid, produced a rapid decrease in the amplitude of the b-wave, while the a-wave was relatively spared. The amplitude of the oscillatory potentials also decreased rapidly. At maximal effect, the electroretinogram essentially consisted of a normal a-wave followed by small oscillations and no evidence of a b-wave. The 100-1000 Hz recording confirmed that the oscillations seen on the postinjection electroretinograms were remnants of the original oscillatory potentials. Kluwer Academic Publishers, 1990 2-amino-4-phosphonobutyric acid nationallicence electroretinogram nationallicence oscillatory potentials nationallicence Guité Pierre Department of Neurology and Neurosurgery, McGill University, Canada aut Lachapelle Pierre Department of Neurology and Neurosurgery, McGill University, Canada aut Documenta Ophthalmologica Kluwer Academic Publishers 75/2(1990-09-01), 125-133 0012-4486 75:2<125 1990 75 10633 https://doi.org/10.1007/BF00146548 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00146548 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guité Pierre Department of Neurology and Neurosurgery, McGill University, Canada aut NATIONALLICENCE 700 1- Lachapelle Pierre Department of Neurology and Neurosurgery, McGill University, Canada aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 75/2(1990-09-01), 125-133 0012-4486 75:2<125 1990 75 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer