caa a22 4500 465794807 CHVBK 20180323112034.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00146546 doi (NATIONALLICENCE)springer-10.1007/BF00146546 Steady-state pattern electroretinogram following long term unilateral administration of timolol to ocular hypertensive subjects [Elektronische Daten] [Ronit Nesher, Gary Trick, Michael Kass, Mae Gordon] To determine whether long-term reduction of intraocular pressure leads to a corresponding preservation of the pattern electroretinogram (PERG), PERGs were studied in 21 patients with ocular hypertension who had received unilateral timolol therapy for a minimum of 6 years. The mean difference in intraocular pressure (IOP) between the placebotreated and the timolol-treated eyes (over 6 years) was 2.4mm Hg. Steady-state PERGs (16.0 rps) were obtained simultaneously in both eyes of each patient, with four check sizes (0.25, 0.5, 1.0 and 2.0 degrees). Significant (p < 0.05) steady-state PERG deficits (i.e., amplitude more than two standard deviations below the mean value of age-matched controls) were observed in 16 eyes of 12 patients (10 placebo-treated and 6 timolol-treated eyes). The mean PERG amplitude did not differ significantly between the placebo-treated and timololtreated eyes. However, a significant correlation (r = - 0.423) in the IOP differences between the placebo-treated and timolol-treated eyes and the corresponding PERG amplitude differences was noted in three of the four test conditions (i.e. 0.25, 0.5, and 1.0 degrees). These results suggest that reducing IOP may preserve ganglion cell function in some patients with ocular hypertension. Kluwer Academic Publishers, 1990 pattern electroretinogram nationallicence timolol nationallicence IOP : intraocular pressure nationallicence PERG : pattern electroretinogram nationallicence Nesher Ronit Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut Trick Gary Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut Kass Michael Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut Gordon Mae Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut Documenta Ophthalmologica Kluwer Academic Publishers 75/2(1990-09-01), 101-109 0012-4486 75:2<101 1990 75 10633 https://doi.org/10.1007/BF00146546 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00146546 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nesher Ronit Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut NATIONALLICENCE 700 1- Trick Gary Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut NATIONALLICENCE 700 1- Kass Michael Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut NATIONALLICENCE 700 1- Gordon Mae Department of Ophthalmology and Visual Science, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, 63110, St Louis, MO, USA aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 75/2(1990-09-01), 101-109 0012-4486 75:2<101 1990 75 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer