caa a22 4500 465794831 CHVBK 20180323112034.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00140498 doi (NATIONALLICENCE)springer-10.1007/BF00140498 The effects of levodopa and haloperidol on flash and pattern ERGs and VEPs in normal humans [Elektronische Daten] [Peter Bartel, Marie Blom, Elna Robinson, Cees Van Der Meyden, Klerk De Sommers, Pieter Becker] We investigated the effects of single doses of the dopamine agonist levodopa and the dopamine antagonist haloperidol on pattern and flash electroretinograms (ERGs) and visual evoked potentials (VEPs) in normal subjects. A placebo and two treatment regimens were administered in a randomized double-masked design. No significant intertreatment differences in the pattern ERGs and VEPs were noted. Although not statistically significant, a clearly discernible tendency was found for increased flash ERG b-wave amplitudes after levodopa administration compared with placebo. In comparison with placebo and levodopa, haloperidol was associated with significantly prolonged flash ERG b-wave implicit times, including each oscillatory potential, which also showed increased duration, particularly in the O1-O3 interpeak implicit time. The failure of pattern ERGs and VEPs to show changes after haloperidol may have been related to the timing of the recordings, which took place during the presumed phase of rising blood levels and before the flash ERG and VEP recordings. Our findings further demonstrated the reliability of the flash ERG in revealing changes in dopaminergic status in the visual system and suggest that steady-state (flicker) ERGs, cone ERGs, and oscillatory potentials have particular use in this regard. Kluwer Academic Publishers, 1990 Dopamine agonist nationallicence dopamine antagonist nationallicence electroretinograms nationallicence visual evoked potentials nationallicence C-ERG : Cone dominated ERG nationallicence M-ERG : ‘mixed' rod and cone ERG nationallicence R-ERG : rod dominated ERG nationallicence S-ERG : steady-state (flicker) ERG nationallicence OP : oscillatory potential nationallicence P-ERG : pattern-reversal ERG nationallicence F-VEP : flash visual evoked potential nationallicence P-VEP : pattern reversal visual evoked potential nationallicence RCT : retinocortical time nationallicence Bartel Peter Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa aut Blom Marie Department of Pharmacology, University of Pretoria, Pretoria, South Africa aut Robinson Elna Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa aut Van Der Meyden Cees Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa aut De Sommers Klerk Department of Pharmacology, University of Pretoria, Pretoria, South Africa aut Becker Pieter Institute for Biostatistics, Medical Research Council, Pretoria, South Africa aut Documenta Ophthalmologica Kluwer Academic Publishers 76/1(1990-11-01), 55-64 0012-4486 76:1<55 1990 76 10633 https://doi.org/10.1007/BF00140498 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00140498 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bartel Peter Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- Blom Marie Department of Pharmacology, University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- Robinson Elna Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- Van Der Meyden Cees Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- De Sommers Klerk Department of Pharmacology, University of Pretoria, Pretoria, South Africa aut NATIONALLICENCE 700 1- Becker Pieter Institute for Biostatistics, Medical Research Council, Pretoria, South Africa aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 76/1(1990-11-01), 55-64 0012-4486 76:1<55 1990 76 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer