caa a22 4500 465794858 CHVBK 20180323112034.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF00140497 doi (NATIONALLICENCE)springer-10.1007/BF00140497 EOG and ERG modifications induced in the chicken eye after blockade of catecholamine and 5-hydroxytryptamine biosynthesis [Elektronische Daten] [G. Rudolf, N. Wioland, E. Kempf, N. Bonaventure] The involvement of catecholaminergic and indoleaminergic systems in the modulation of the standing potential of the eye was tested in chickens by means of an indirect electrooculography method and direct current electroretinogram recordings. D,L α- monofluoromethyl dopa (MFMD), 50 and 100 nmol), a highly specific inactivator of aromatic L-amino acid decarboxylase, was injected intravitreally. This treatment is known to induce a selective and irreversible blockade of dopamine and 5-hydroxytryptamine biosynthesis. Five hours after drug injection an important increase in the standing potential appeared. The light peak was delayed by about 5 min but its amplitude was unchanged. The return of the standing potential to basal value during maintained illumination was delayed by 5-10 min. The time course of the dark trough was not modified. The intensity-voltage functions were also studied for the various electroretinogram components, 5 hr after MFMD. The voltage of the b-wave was reduced (by 65% with the highest intensity), while the other components were little affected. Substantial reduction in dopamine and 5-hydroxytryptamine concentrations were found in treated retinas. These data, together with previous results, suggest that the standing potential of the chicken eye may be modulated by a balance between catecholamine and indoleamine systems. Kluwer Academic Publishers, 1990 Biosynthesis inhibitors nationallicence chicken nationallicence dopamine nationallicence electrooculogram nationallicence lectroretinogram nationallicence 5-hydroxytryptamine nationallicence Rudolf G. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut Wioland N. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut Kempf E. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut Bonaventure N. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut Documenta Ophthalmologica Kluwer Academic Publishers 76/1(1990-11-01), 47-53 0012-4486 76:1<47 1990 76 10633 https://doi.org/10.1007/BF00140497 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00140497 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rudolf G. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut NATIONALLICENCE 700 1- Wioland N. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut NATIONALLICENCE 700 1- Kempf E. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut NATIONALLICENCE 700 1- Bonaventure N. D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France aut NATIONALLICENCE 773 0- Documenta Ophthalmologica Kluwer Academic Publishers 76/1(1990-11-01), 47-53 0012-4486 76:1<47 1990 76 10633 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer