caa a22 4500 465795102 CHVBK 20180323112035.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF00308561 doi (NATIONALLICENCE)springer-10.1007/BF00308561 Evolution of the NS genes of the influenza a viruses. I. The genetic relatedness of the NS genes of animal influenza viruses [Elektronische Daten] [Katsuhisa Nakajima, Eri Nobusawa, Takashi Ogawa, Setsuko Nakajima] We compared the nucleotide sequences of the NS genes of 13 animal influenza viruses belonging to human, swine, avian, and equine viruses for the study of the genetic relatedness of the NS genes in animal influenza viruses. The NS genes of three virus strains A/chicken/Brescia/02, A/equine/Prague/56, and A/equine/Miami/63 were newly sequenced. The base sequence homologies between the NS genes of avian, human, swine, and the A/equine/Miami/63 viruses were 87.8% or higher. On the other hand, the base sequence of the NS gene of the A/equine/Prague/56 virus differed widely from those of other viruses analyzed in the present study. We constructed a model of the genetic tree of the NS genes of avian and equine influenza viruses by a modified Farris method (1). For comparison of the NS genes between human and avian viruses, we estimated the speed of the nucleotide substitutions of the avian influenza NS genes. It was roughly constant, even though the substitutions did not occur sequentially. The nucleotide substitution rate of the NS genes of avian influenza viruses was one-third to one-fourth that of human influenza viruses. We deduced the time of separation between the NS genes of human and avian influenza viruses during evolution. Kluwer Academic Publishers, 1990 influenza A viruses nationallicence NS gene nationallicence evolution nationallicence Nakajima Katsuhisa Institute of Medical Science, Tokyo, Japan aut Nobusawa Eri Institute of Medical Science, Tokyo, Japan aut Ogawa Takashi National Institute of Animal Health, Ibaraki, Japan aut Nakajima Setsuko Institute of Public Health, Tokyo, Japan aut Virus Genes Kluwer Academic Publishers 4/1(1990-06-01), 5-13 0920-8569 4:1<5 1990 4 11262 https://doi.org/10.1007/BF00308561 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00308561 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakajima Katsuhisa Institute of Medical Science, Tokyo, Japan aut NATIONALLICENCE 700 1- Nobusawa Eri Institute of Medical Science, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogawa Takashi National Institute of Animal Health, Ibaraki, Japan aut NATIONALLICENCE 700 1- Nakajima Setsuko Institute of Public Health, Tokyo, Japan aut NATIONALLICENCE 773 0- Virus Genes Kluwer Academic Publishers 4/1(1990-06-01), 5-13 0920-8569 4:1<5 1990 4 11262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer