caa a22 4500 46579517X CHVBK 20180323112035.0 cr unu---uuuuu 170327e19900901xx s 000 0 eng 10.1007/BF00265636 doi (NATIONALLICENCE)springer-10.1007/BF00265636 Becker Yechiel Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel aut Computer analysis of antigenic domains and RGD-like sequences (RGWG) in the E glycoprotein of flaviviruses: An approach to vaccine development [Elektronische Daten] [Yechiel Becker] Antigenic domains and RGD-like sequences in the E glycoprotein of the flaviviruses Japanese encephalitis virus, yellow fever virus, West Nile virus, dengue type 4 virus, and tick-borne encephalitis virus were analyzed by computer programs that provide information on the physical properties of the polypeptides. The use of computer programs for the development of vaccines based on the synthesis of antigenic peptides is discussed. Synthetic viral peptides are proposed to be used for topical application so as to interfere with the virus-cell interaction. Viral peptides with antigenic epitopes to protect against dengue virus infection without enhancing pathogenesis may also be developed on the basis of the computer analysis. Kluwer Academic Publishers, 1990 computer analysis of viral proteins nationallicence dengue type 4 nationallicence flavivirus E glycoprotein nationallicence Japanese encephalitis virus nationallicence tick-borne encephalitis virus nationallicence West Nile virus nationallicence yellow fever virus nationallicence Virus Genes Kluwer Academic Publishers 4/3(1990-09-01), 267-282 0920-8569 4:3<267 1990 4 11262 https://doi.org/10.1007/BF00265636 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00265636 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Becker Yechiel Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel aut NATIONALLICENCE 773 0- Virus Genes Kluwer Academic Publishers 4/3(1990-09-01), 267-282 0920-8569 4:3<267 1990 4 11262 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer