caa a22 4500 46579629X CHVBK 20180323112038.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02541849 doi (NATIONALLICENCE)springer-10.1007/BF02541849 Gamma-irradiation of 7-ketocholesterol in aqueous dispersions and liposomes [Elektronische Daten] [Nancy Moriarity, Gerhard Maerker] 7-Ketocholesterol in aqueous sodium stearate dispersions or incorporated into liposomes was exposed to gamma radiation at 0-4°C to a dose of 50 kGy. Substrate degradation was noted in all systems, but occurred to a much greater extent in dispersions (≈90%) than in liposomes (0-25%). The difference in degree of degradation is attributed to dissimilarities in the micro-environment of 7-ketocholesterol in the two systems. The principal decomposition product was identified as 7-ketocholestanol, a compound that can arise from hydrogenation of the double bond of the starting material. Also detected, but in lower concentration, were the epimeric 7-hydroxycholesterols resulting from the reduction of the original carbonyl function. Both 7-ketocholestanol and the epimeric 7-hydroxycholesterols are believed to be secondary species generated by the interaction of the starting material with the primary radiolysis products of water. In addition, many minor degradation products were noted but not identified. American Oil Chemists' Society (AOCS), 1990 Gamma irradiation nationallicence 7-ketocholestanol nationallicence 7-ketocholesterol nationallicence liposomes nationallicence radiation-induced degradation nationallicence sodium stearate dispersions nationallicence Moriarity Nancy Eastern Regional Research Center, U.S. Department of Agriculture, ARS, 600 East Mermaid Lane, 19118, Philadelphia, PA aut Maerker Gerhard Eastern Regional Research Center, U.S. Department of Agriculture, ARS, 600 East Mermaid Lane, 19118, Philadelphia, PA aut Journal of the American Oil Chemists' Society Springer-Verlag 67/12(1990-12-01), 923-926 0003-021X 67:12<923 1990 67 11746 https://doi.org/10.1007/BF02541849 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02541849 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moriarity Nancy Eastern Regional Research Center, U.S. Department of Agriculture, ARS, 600 East Mermaid Lane, 19118, Philadelphia, PA aut NATIONALLICENCE 700 1- Maerker Gerhard Eastern Regional Research Center, U.S. Department of Agriculture, ARS, 600 East Mermaid Lane, 19118, Philadelphia, PA aut NATIONALLICENCE 773 0- Journal of the American Oil Chemists' Society Springer-Verlag 67/12(1990-12-01), 923-926 0003-021X 67:12<923 1990 67 11746 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer