caa a22 4500 465803520 CHVBK 20180323112058.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03348575 doi (NATIONALLICENCE)springer-10.1007/BF03348575 Pro-gamma-MSH levels in various disorders of pituitary-adrenal axis [Elektronische Daten] [Marco Boscaro, R. Giacomazzi, N. Sonino, F. Fallo, F. Girard, X. Bertagna, F. Mantero] N-Terminal (1-76) portion of proopiomelanocortin (hNT) was measured in normals, Addison's, Nelson's, Cushing's disease, and in dexa-methasone suppressible hyperaldosteronism (DSH) by using a specific homologous RIA. Mean basal immunoreactive hNT level was 94.2 ± 6 pg/ml (mean ± SE) in normal subjects. In Cushing's disease hNT values were slightly but not significantly (121 ± 26.5 pg/ml) higher. In patients with DSH the levels were within normal range while they were much higher in Addison's and Nelson's syndromes. A strong correlation was found between IR-hNT and ACTH in plasma of normal subjects and patients with different disorders of the pituitary-adrenal axis (r = 0.83, p < 0.01). Corticotropin-Releasing-Hormone (CRH) test in Cushing's disease stimulated the release of both ACTH and IR-hNT, showing a slightly different pattern of secretion. Similar patterns of secretion were found for hNT and ACTH in various pituitary-adrenal abnormalities. Normal levels of hNT in DSH do not support a role of this peptide in the pathogenesis of the disorder. Measurement of hNT in plasma can provide an additional tool for the diagnosis of patients with various disorders of the hypothalamic-pituitary-adrenal axis. Italian Society of Endocrinology (SIE), 1990 Proopiomelanocortin nationallicence radioimmunoassay nationallicence Cushing's syndrome nationallicence Addison's disease nationallicence Nelson's syndrome nationallicence Boscaro Marco Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut Giacomazzi R. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut Sonino N. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut Fallo F. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut Girard F. Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, France aut Bertagna X. Centre de Recherche sur les Maladies Endocriniennes, Hôpital Cochin, Paris, France aut Mantero F. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 29-33 0391-4097 13:1<29 1990 13 40618 https://doi.org/10.1007/BF03348575 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348575 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boscaro Marco Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Giacomazzi R. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Sonino N. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Fallo F. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Girard F. Laboratoire d'Explorations Fonctionnelles, Hôpital Trousseau, France aut NATIONALLICENCE 700 1- Bertagna X. Centre de Recherche sur les Maladies Endocriniennes, Hôpital Cochin, Paris, France aut NATIONALLICENCE 700 1- Mantero F. Istituto di Semeiotica Medica, Universita di Padova, Via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 29-33 0391-4097 13:1<29 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer