caa a22 4500 465803547 CHVBK 20180323112058.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03348574 doi (NATIONALLICENCE)springer-10.1007/BF03348574 Regional differences in the response of cardiac cells to triiodothyronine administration across the left ventricle free wall of rat heart [Elektronische Daten] [V. De Tata, Z. Gori, Ettore Bergamini] We have studied the effect of T3 administration (50μg/Kg/day) on the phenotype expression of several glucose-metabolizing enzymes (hexokinase, HK, glucose-6-phosphate dehydrogenase, G6P-DH, aldolase, ALD, phosphofructoki-nase, PFK, lactate dehydrogenase, LDH) in the different myocardial layers of the left ventricle wall. In the control rats, most of these enzyme activities are uniformly distributed across the left ventricle wall, G6P-DH being the only exception. In the rats given T3 for 14 days, the mean levels of PFK, HK and ALD activities increased significantly. With regard to the transmural distribution patterns, that of PFK was unchanged, unlike those of HK and ALD which exhibited their maximum increase in activity in the midmyocardium or in the mid- and subepicardial myocardium. With LDH, a significant increase in activity was found in the subepicardial layers which escaped detection on the whole ho-mogenate. It is concluded that the administration of thyroid hormone has different effects on enzyme phenotype expression of cardiomyocytes in different regions of the cardiac wall. Italian Society of Endocrinology (SIE), 1990 Rat heart nationallicence hyperthyroidism (experimental) nationallicence hexokinase nationallicence glu-cose-6-phosphate dehydrogenase nationallicence aldolase nationallicence phosphofructokinase nationallicence lactate dehydrogenase nationallicence De Tata V. Istituto di Patologia Generale, Il Cattedra, Università di Pisa, via Roma 55, Scuola Medica, 56100, Pisa, Italy aut Gori Z. Istituto di Patologia Generale, Il Cattedra, Università di Pisa, via Roma 55, Scuola Medica, 56100, Pisa, Italy aut Bergamini Ettore Istituto di Patologia Generale, Il Cattedra, Università di Pisa, via Roma 55, Scuola Medica, 56100, Pisa, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 25-28 0391-4097 13:1<25 1990 13 40618 https://doi.org/10.1007/BF03348574 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348574 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Tata V. Istituto di Patologia Generale, Il Cattedra, Università di Pisa, via Roma 55, Scuola Medica, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Gori Z. Istituto di Patologia Generale, Il Cattedra, Università di Pisa, via Roma 55, Scuola Medica, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Bergamini Ettore Istituto di Patologia Generale, Il Cattedra, Università di Pisa, via Roma 55, Scuola Medica, 56100, Pisa, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 25-28 0391-4097 13:1<25 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer