caa a22 4500 465803628 CHVBK 20180323112058.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03348579 doi (NATIONALLICENCE)springer-10.1007/BF03348579 Expression of HLA ABC and DR antigens in thyroid neoplasia and correlation with mononuclear leukocyte infiltration [Elektronische Daten] [M. Fisfalen, W. Franklin, L. DeGroot, R. Cajulis, K. Soltani, M. Ryan, N. Jones] The rejection of tumor cells by the immune system depends on the production of tumor-associated antigens and the expression of HLA antigens on these cells. We therefore studied the expression of HLA ABC and PR antigens in malignant and benign thyroid disorders and correlated it with the types and extent of mononuclear cell infiltration. In the normal thyroid, HLA ABC expression was weak and focal, while it was diffusely present in benign disorders and in most but not all malignancies. HLA DR antigens, while absent or infrequently expressed in normal thyroid, were strongly but often focally expressed in all cases of autoimmune thyroid disease (AITD), as well as in most cases of malignant tumors and benign epithelium surrounding these tumors, and colloid nodule diesase. There was a T cell predominance in all disorders, and the CD4VCD8+ ratio was > 1 in most benign and malignant specimens. There was a direct correlation between the high expression of HLA antigens and dense inflammatory infiltration in AITD but not in most tumor specimens. Lack of such correlation suggests that the expression of HLA antigens is an autonomous event in tumors, independent of cellular infiltrate. Italian Society of Endocrinology (SIE), 1990 Antigen nationallicence epithelium nationallicence infiltration nationallicence autoimmune nationallicence expression nationallicence lymphocyte nationallicence monoclonal antibodies nationallicence Fisfalen M. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut Franklin W. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut DeGroot L. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut Cajulis R. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut Soltani K. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut Ryan M. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut Jones N. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 41-48 0391-4097 13:1<41 1990 13 40618 https://doi.org/10.1007/BF03348579 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348579 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fisfalen M. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 700 1- Franklin W. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 700 1- DeGroot L. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 700 1- Cajulis R. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 700 1- Soltani K. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 700 1- Ryan M. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 700 1- Jones N. The Thyroid Study Unit, Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Box 138, IL 60637, Chicago, USA aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 41-48 0391-4097 13:1<41 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer