caa a22 4500 465803644 CHVBK 20180323112058.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF03348582 doi (NATIONALLICENCE)springer-10.1007/BF03348582 Glucose and insulin suppression of plasma free fatty acids in obese subjects with normal glucose tolerance or mild, newly diagnosed Type 2 (non-insulin-dependent) diabetes [Elektronische Daten] [C. Zancanaro, M. Cigolini, E. Bonora, P. Moghetti, M. Querena, M. Muggeo] The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/I). Somatostatin was infused (250 μg/h) during the third h of glucose clamp to inhibit glucose-stimulated insulin secretion. Plasma insulin values were similar in the two groups at fasting and all throughout the study (F = 0.04; p = NS, two way analysis of variance), while the amount of glucose metabolized during the clamp was lower in diabetic subjects. Plasma free fatty acid concentrations, which were similar in the two groups at fasting, decreased during hyperglycemia and glucose-induced hyperinsulinemia (0-120 min; 180-240 min), and rose during hyperglycemia and somatostatin-inhibited insulin secretion (120-180 min). However, plasma free fatty acid concentrations were significantly higher in diabetic subjects all along the study period both in absolute terms (F = 11.4; p < 0.0001) and when individual data were recalculated as percent of fasting value (F = 13.3; p < 0.0001). Our data suggest that suppressibility of fasting plasma free fatty acids is lower in obese Type 2 diabetes in comparison with obese non-diabetic subjects. Italian Society of Endocrinology (SIE), 1990 Free fatty acid nationallicence Type 2 (non-insulin-dependent-diabetes) nationallicence obesity nationallicence Insulin nationallicence glucose clamp nationallicence Zancanaro C. Istituto di Clinica Medica, Universita di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut Cigolini M. Istituto di Clinica Medica, Universita di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut Bonora E. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut Moghetti P. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut Querena M. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut Muggeo M. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 55-59 0391-4097 13:1<55 1990 13 40618 https://doi.org/10.1007/BF03348582 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348582 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zancanaro C. Istituto di Clinica Medica, Universita di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Cigolini M. Istituto di Clinica Medica, Universita di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Bonora E. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Moghetti P. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Querena M. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Muggeo M. Cattedra di Malattie del Metabolismo, Università di Verona, Policlinico BorgoRoma, 37134, Verona, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/1(1990-01-01), 55-59 0391-4097 13:1<55 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer