caa a22 4500 465803849 CHVBK 20180323112058.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF03348605 doi (NATIONALLICENCE)springer-10.1007/BF03348605 HLA-DR4 associated response to corticosteroids in Graves' ophthalmopathy patients [Elektronische Daten] [R. van der Gaag, W. Wiersinga, L. Koornneef, M. Mourits, M. Prummel, A. Berghout, R. de Vries, G. Schreuder, J. D'Amaro] Fifty-seven patients with severe Graves' ophthalmopathy were treated with corticosteroids. Therapeutic outcome was assessed according to predetermined criteria as response (n = 37) or non-response (n = 20) to therapy. Patients were typed for HLA-A, -B, -C, -DR and -DQ. HLA-DR4 was completely absent in the 20 non-responder patients (corrected p value = 0.042). In the responder group 14 of the 37 patients were HLA-DR4 positive. This study shows that in Graves' ophthalmopathy patients the presence of HLA-DR4 is associated with a good response to corticosteroid therapy. The frequency of HLA-DR4 in the Graves' ophthalmopathy population as a whole, however, was not different from normal (25% versus 26%). But as reported previously, the frequency of HLA-DR3 was significantly increased in the Graves' ophthalmopathy patients when compared to healthy blood donors (47% versus 24%, corrected p value = 0.02). No significant deviations were found in the HLA-A, -B, or -C loci. Italian Society of Endocrinology (SIE), 1990 HLA-DR4 nationallicence Graves' ophthalmopathy nationallicence corticosteroid nationallicence van der Gaag R. Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, P.O. Box 12141, 1100 AC, Amsterdam, The Netherlands aut Wiersinga W. Division of Endocrinology, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands aut Koornneef L. Orbital Centre, Department of Ophthalmology, Academic Medical Centre, Amsterdam, The Netherlands aut Mourits M. Orbital Centre, Department of Ophthalmology, Academic Medical Centre, Amsterdam, The Netherlands aut Prummel M. Division of Endocrinology, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands aut Berghout A. Division of Endocrinology, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands aut de Vries R. Department of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands aut Schreuder G. Department of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands aut D'Amaro J. Department of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands aut Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 489-492 0391-4097 13:6<489 1990 13 40618 https://doi.org/10.1007/BF03348605 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348605 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van der Gaag R. Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, P.O. Box 12141, 1100 AC, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Wiersinga W. Division of Endocrinology, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Koornneef L. Orbital Centre, Department of Ophthalmology, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Mourits M. Orbital Centre, Department of Ophthalmology, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Prummel M. Division of Endocrinology, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Berghout A. Division of Endocrinology, Department of Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- de Vries R. Department of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Schreuder G. Department of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands aut NATIONALLICENCE 700 1- D'Amaro J. Department of Immunohematology and Bloodbank, University Hospital, Leiden, The Netherlands aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 489-492 0391-4097 13:6<489 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer