caa a22 4500 465803903 CHVBK 20180323112058.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF03348612 doi (NATIONALLICENCE)springer-10.1007/BF03348612 Inhibitory effects of centrally administered ASU1-7 eel calcitonin on basal and stimulated prolactin release in rats [Elektronische Daten] [V. Sibilia, C. Netti, F. Guidobono, I. Villa, A. Pecile] We investigated the effects of /ASU1-7/eel calcitonin (ASU1-7 elCT) on basal and stimulated prolactin (PRL) release in male rats. /ASU1-7/eelCT was administered intracerebroventricularly (icv) into freely moving rats with indwelling catheters. The administration of /ASU1-7/eelCT (2.5 μ/rat, icv) significantly inhibited basal PRL secretion. When PRL secretion was stimulated by exposing rats to restraint stress, /ASU1-7/eelCT (250 ng; 800 ng; 2.5 μ/rat, icv) dose-relatedly inhibited the PRL surges at 10 min after stress. The same doses of icv /ASU1-7/eelCT were effective in inhibiting morphine (6 mg/kg, intracarotid, ia)-induced PRL release. No effect on stress-induced PRL secretion was observed when the peptide was administered intracarotid at the dose of 10 μ/rat. These results demonstrate that /ASU1-7/eelCT, as we previously observed with salmon calcitonin (sCT), has central inhibitory activity on PRL secretion, probably through enhancement of hypothalamic inhibitory pathways involved in the control of PRL. Italian Society of Endocrinology (SIE), 1990 |ASU1-7| eel calcitonin nationallicence PRL nationallicence stress nationallicence morphine nationallicence Sibilia V. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Netti C. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Guidobono F. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Villa I. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Pecile A. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 507-511 0391-4097 13:6<507 1990 13 40618 https://doi.org/10.1007/BF03348612 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sibilia V. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 700 1- Netti C. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 700 1- Guidobono F. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 700 1- Villa I. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 700 1- Pecile A. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Università di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 507-511 0391-4097 13:6<507 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer