caa a22 4500 465803938 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF03348621 doi (NATIONALLICENCE)springer-10.1007/BF03348621 Effect of acipimox, a lipid lowering drug, on growth hormone (GH) response to GH-releasing hormone in normal subjects [Elektronische Daten] [A. Pontiroli, R. Lanzi, L. Monti, G. Pozza] Growth hormone (GH) induces lipolysis and an increase of free fatty acids (FFA), and FFA inhibit the GH response to arginine and to GH-releasing hormone (GHRH). The aim of this study was to evaluate the effect of the pharmacologic blockade of lipolysis on the GH response to GHRH. Eleven normal men underwent a saline infusion starting at 09:00 h, after administration of placebo or 500 mg acipimox, an antilipolytic agent; at 13:00 h (0 min) they received GHRH, 50 jig iv The GH response to GHRH (0 to 120 min) was significantly higher in subjects pretreated with acipimox than in subjects pretreated with placebo. In subjects receiving placebo, but not in those receiving acipimox, a progressive increase of plasma FFA levels took place, and the GH response to GHRH was inversely related to the plasma FFA levels at 0 min. These data indicate that FFA play an important role in the control of GH release, and that acipimox prevents the FFA rise induced by GH. Italian Society of Endocrinology (SIE), 1990 Growth hormone nationallicence GHRH nationallicence free fatty acids (FFA, NEFA) nationallicence acipimox nationallicence Pontiroli A. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut Lanzi R. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut Monti L. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut Pozza G. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 539-542 0391-4097 13:6<539 1990 13 40618 https://doi.org/10.1007/BF03348621 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348621 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pontiroli A. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut NATIONALLICENCE 700 1- Lanzi R. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut NATIONALLICENCE 700 1- Monti L. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut NATIONALLICENCE 700 1- Pozza G. Istituto Scientifico San Raffaele, Cattedra di Clinica Medica, Università degli Studi di Milano, Via Olgettina 60, 20132, Milano, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 539-542 0391-4097 13:6<539 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer