caa a22 4500 465803946 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF03348606 doi (NATIONALLICENCE)springer-10.1007/BF03348606 The effect of methimazole on the immune system is unlikely to operate directly on T lymphocytes [Elektronische Daten] [M. Bagnasco, D. Venuti, G. Ciprandi, G. Pesce, F. Paolieri, G. Canonica] It has been shown that the antithyroid drug methimazole (MMI) may affect B cells and possibly accessory cell function. In the present study we investigated in detail the effects of MMI on T cell in vitro proliferation. The following variables were evaluated: T cell proliferation following stimulation with phytohemoagglutinin (PHA), and anti-CD3 or anti-CD2 monoclonal antibodies; in-terleukin-2 (IL-2) and gamma-interferon (gamma-IFN) production by PHA-stimulated T cells in bulk culture and by T cell clones; PHA-induced IL-2 receptor expression; LPS-induced interleukin-1 production by accessory cells. The results obtained failed to demonstrate any effect of MMI on T cells in vitro proliferation, whatever the activation pathway considered. In addition, IL-2 and gamma-IFN productions were substantially unaffected by the drug, as well as IL-1 production by accessory cells. However, a slight reduction of PHA-induced IL-2 receptor expression was observed. Although the hypothesis of an effect of MMI on some specialized T cell functions cannot be ruled out, it is likely that the supposed "immunosuppressive” effect of the drug does not concern primarily the T lymphocyte. Italian Society of Endocrinology (SIE), 1990 Thyroid nationallicence methimazole nationallicence hyperthyroidism nationallicence T-cells nationallicence interleukins nationallicence Bagnasco M. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut Venuti D. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut Ciprandi G. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut Pesce G. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut Paolieri F. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut Canonica G. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 493-499 0391-4097 13:6<493 1990 13 40618 https://doi.org/10.1007/BF03348606 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348606 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bagnasco M. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut NATIONALLICENCE 700 1- Venuti D. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut NATIONALLICENCE 700 1- Ciprandi G. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut NATIONALLICENCE 700 1- Pesce G. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut NATIONALLICENCE 700 1- Paolieri F. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut NATIONALLICENCE 700 1- Canonica G. Istituto Scientifico di Medicina Interna, Centro di Immunoendocrinologia and Centro di Allergologia, Università di Genova, 16100, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 493-499 0391-4097 13:6<493 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer