caa a22 4500 465803954 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF03348603 doi (NATIONALLICENCE)springer-10.1007/BF03348603 GHRH-test in short children with "non classic” GH deficiency. A comparison with "classic” GH deficiency and short normal stature [Elektronische Daten] [Giuseppe Saggese, G. Cesaretti, N. Giannessi, L. Cinquanta, C. Bracaloni, C. Cioni, G. Di Spigno, R. Di Porto] In this study GHRH-test has been performed (2 μg/Kg of an iv bolus of GHRH 1-44) sampling for GH measurement every 15 min over 2 hours in three groups of short children. Group 1 consisted of 10 subjects with classic GH deficiency (CGHD): GH response < 10 ng/ml to two conventional tests and 24-h mean GH concentration (MGHC) < 3 ng/ml; group 2 consisted of 16 subjects with non-classic GH deficiency (NCGHD): response > 10 ng/ml to at least one conventional test and MGHC < 3 ng/ml; group 3 consisted of 18 subjects with short normal stature: GH response > 10 ng/ml to at least one conventional test and MGHC >3 ng/ml. GH peak and area under the curve (AUC) values were significantly lower in group 1 than groups 2 and 3 and in group 2 than group 3. GH peak and AUC values statistically correlated with height, height velocity, bone age/chronological age ratio and MGHC. Six children in group 1,14 children in group 2 and all 18 children in group 3 showed after GHRH a GH peak > 10 ng/ml and were considered as ‘responders'. Considering only the responders, GH peak and AUC values were significantly lower in group 1 than groups 2 and 3 and in group 2 than group 3. In conclusion, our data have shown that 87% of children with NCGHD responded to a single bolus of GHRH with an increase in GH levels > 10 ng/ml and that their responses were intermediate compared to those of CGHD and short normal subjects. Italian Society of Endocrinology (SIE), 1990 GHRH-test nationallicence classic and non-classic GH deficiency nationallicence short normal stature nationallicence Saggese Giuseppe Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Cesaretti G. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Giannessi N. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Cinquanta L. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Bracaloni C. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Cioni C. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Di Spigno G. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Di Porto R. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 475-480 0391-4097 13:6<475 1990 13 40618 https://doi.org/10.1007/BF03348603 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348603 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saggese Giuseppe Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Cesaretti G. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Giannessi N. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Cinquanta L. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Bracaloni C. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Cioni C. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Di Spigno G. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Di Porto R. Clinica Pediatrica, Università di Pisa, Via Roma, 35, 56100, Pisa, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 475-480 0391-4097 13:6<475 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer