caa a22 4500 465803997 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF03348618 doi (NATIONALLICENCE)springer-10.1007/BF03348618 Amiodarone-induced thyrotoxicosis suggestive of thyroid damage [Elektronische Daten] [Michel Lambert, J. Unger, P. Nayer, C. Brohet, D. Gangji] Amiodarone-induced thyrotoxicosis (AIT) is generally believed to result from increased hormonal synthesis related to the iodine overload. Thyroid damage has recently been incriminated as a pathophysiological mechanism. We report 3 cases of AIT associated with clinical and/or biochemical features consistent with thyroid damage. This hypothesis was supported by a painful thyroid (case 1 ), transient high serum Tg (case 2), a transient (case 2) or persistent (case 3) hypothyroid phase and an undetectable technetium thyroid uptake during the hypothyroid period (case 3). These clinical observations support the previous histological data indicating that thyroid follicular disruption might contribute to the pathogenesis of AIT. Italian Society of Endocrinology (SIE), 1990 Amiodarone nationallicence thyrotoxicosis nationallicence thyroiditis nationallicence thyroid damage nationallicence Lambert Michel Department of Internal Medicine, Saint-Luc University Hospital, 10, avenue Hippocrate, B-1200, Brussels, Belgium aut Unger J. Department of Endocrinology, Erasme University Hospital, Free University of Brussels, B-1070, Brussels, Belgium aut Nayer P. Department of Nuclear Medicine, Saint-Luc University Hospital, Louvain Medical School, B-1200, Brussels, Belgium aut Brohet C. Department of Internal Medicine, Saint-Luc University Hospital, 10, avenue Hippocrate, B-1200, Brussels, Belgium aut Gangji D. Department of Pharmacology, Erasme University Hospital, Free University of Brussels, B-1070, Brussels, Belgium aut Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 527-530 0391-4097 13:6<527 1990 13 40618 https://doi.org/10.1007/BF03348618 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348618 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lambert Michel Department of Internal Medicine, Saint-Luc University Hospital, 10, avenue Hippocrate, B-1200, Brussels, Belgium aut NATIONALLICENCE 700 1- Unger J. Department of Endocrinology, Erasme University Hospital, Free University of Brussels, B-1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Nayer P. Department of Nuclear Medicine, Saint-Luc University Hospital, Louvain Medical School, B-1200, Brussels, Belgium aut NATIONALLICENCE 700 1- Brohet C. Department of Internal Medicine, Saint-Luc University Hospital, 10, avenue Hippocrate, B-1200, Brussels, Belgium aut NATIONALLICENCE 700 1- Gangji D. Department of Pharmacology, Erasme University Hospital, Free University of Brussels, B-1070, Brussels, Belgium aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/6(1990-06-01), 527-530 0391-4097 13:6<527 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer