caa a22 4500 465804071 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03349612 doi (NATIONALLICENCE)springer-10.1007/BF03349612 Usefulness of the combined antithyroglobulin antibodies and thyroglobulin assay in the follow-up of patients with differentiated thyroid cancer [Elektronische Daten] [D. Rubello, M. Girelli, D. Casara, M. Piccolo, A. Perin, Benedetto Busnardo] A total of 1050 patients with differentiated thyroid cancer (DTC) have been followed in the Thyroid Center of Padua by means of serum thyroglobulin (Tg) measured with IRMA method and anti-Tg antibodies (TgAb) assays. Circulating TgAbs were detected in 102 (9.7%) patients. In 32 of these 102, TgAbs were evaluated before and after total thyroidectomy and 131l ablation. In these patients no relationship was found between preoperative serum TgAb levels on the one hand and tumor stage at diagnosis or outcome of the disease on the other. During the follow-up, TgAb serum levels decreased or disappeared in 21 cases considered tumor-free, while they remained unchanged or even increased, in comparison with the preoperative ones, in 11 patients, 5 with proven metastases and 6 considered tumor-free. Evaluating the whole group of 102 TgAb-positive patients, we observed that TgAb serum levels, measured after thyroid ablation, were significantly higher in cases with metastases than in those considered tumor-free (653.0 ± 196.9 vs 157.7 ± 116.5 U/ml, m ± SD, p < 0.0001). In the group of patients with metastases and circulating TgAbs, Tg serum levels were elevated in 27% of cases on TSH- suppressive therapy and in 44% off therapy when nodal metastases were present, and in 67% of cases on TSH-suppressive therapy and in 83% off therapy when distant metastases were present. Our data suggest that: i) In a very large series of patients with DTC, circulating TgAbs are detectable in 9.7% of cases; ii) In the follow-up, patients with high TgAb serum levels even in absence of detectable serum Tg values are at risk for metastases; in fact circulating TgAbs might be due to the presence of tumor and circulating TgAbs themselves may prevent the detection of serum Tg; iii) serum IRMA-Tg assay appears to maintain its value as a tumoral marker in more than half the patients with metastases and circulating TgAbs. Italian Society of Endocrinology (SIE), 1990 Serum thyroglobulin nationallicence antithyroglobulin antibodies nationallicence thyroid cancer nationallicence Rubello D. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut Girelli M. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut Casara D. Divisione di Radioterapia e Medicina Nucleare, Ospedale di Padova, Via Ospedale 105, 35100, Padova, Italy aut Piccolo M. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut Perin A. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut Busnardo Benedetto Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/9(1990-10-01), 737-742 0391-4097 13:9<737 1990 13 40618 https://doi.org/10.1007/BF03349612 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rubello D. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Girelli M. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Casara D. Divisione di Radioterapia e Medicina Nucleare, Ospedale di Padova, Via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Piccolo M. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Perin A. Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 700 1- Busnardo Benedetto Istituto di Semeiotica Medica, University of Padova, via Ospedale 105, 35100, Padova, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/9(1990-10-01), 737-742 0391-4097 13:9<737 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer