caa a22 4500 465804101 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03349603 doi (NATIONALLICENCE)springer-10.1007/BF03349603 The morphometric analysis of cell nuclei from fine needle aspirates of thyroid follicular lesions does not improve the diagnostic accuracy of traditional cytologic examination [Elektronische Daten] [G. La Rosa, V. Cavallari, D. Giuffrida, S. Scimone, G. La Porta, M. Maiorana, A. Maiorana, A. Belfiore] In order to evaluate the usefulness of the morphometric analysis in improving the accuracy of the traditional cytologic examination of follicular thyroid lesions, fine needle aspirates from 17 adenomatous goiters, 19 follicular adenomas and 18 follicular carcinomas were examined. In each case 20-50 follicles, accounting from 100 to 200 thyroid cells, were studied by operators unaware of the histologic diagnosis. Nuclear areas (mean, maximum and minimum area) were derived by means of a semiautomatic system and follicular thyroid lesions were classified into three groups (goiter, adenoma and follicular carcinoma) utilizing cut-off values. The results were then compared to the cytologic diagnosis carried out according to traditional (optic microscopy) criteria. Mean values of nuclear areas showed significant differences among the three groups, but a considerable overlap occurred in the size distribution of cell nuclei. At present, therefore, planimetric measurements of cell nuclei in fine needle aspirates do not improve the accuracy of standard cytologic examination in the differential diagnosis of follicular thyroid lesions. Italian Society of Endocrinology (SIE), 1990 Morphometry nationallicence thyroid follicular lesions nationallicence follicular carcinomas nationallicence fine needle aspiration biopsy nationallicence La Rosa G. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut Cavallari V. Dipartimento di Patologia Umana, University of Messina, 98100, Messina, Italy aut Giuffrida D. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut Scimone S. Dipartimento di Patologia Umana, University of Messina, 98100, Messina, Italy aut La Porta G. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut Maiorana M. Dipartimento di Patologia Umana, University of Messina, 98100, Messina, Italy aut Maiorana A. Istituto di Anatomia Patologica, University of Modena, 41100, Modena, Italy aut Belfiore A. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/9(1990-10-01), 701-707 0391-4097 13:9<701 1990 13 40618 https://doi.org/10.1007/BF03349603 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349603 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- La Rosa G. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut NATIONALLICENCE 700 1- Cavallari V. Dipartimento di Patologia Umana, University of Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Giuffrida D. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut NATIONALLICENCE 700 1- Scimone S. Dipartimento di Patologia Umana, University of Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- La Porta G. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut NATIONALLICENCE 700 1- Maiorana M. Dipartimento di Patologia Umana, University of Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Maiorana A. Istituto di Anatomia Patologica, University of Modena, 41100, Modena, Italy aut NATIONALLICENCE 700 1- Belfiore A. Cattedra di Endocrinologia, Ospedale Garibaldi, USL 34, University of Catania, Piazza S. Maria di Gesù, 95124, Catania, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/9(1990-10-01), 701-707 0391-4097 13:9<701 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer