caa a22 4500 465804160 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF03349615 doi (NATIONALLICENCE)springer-10.1007/BF03349615 Repeated transient hypergonadotropic amenorrhea during pharmacologic induction of multiple follicular development with exogenous gonadotropins [Elektronische Daten] [V. Mais, Gian Melis, D. Antinori, A. Paoletti, F. Strigini, S. Guerriero, A. de Ruggiero, P. Rioretti] Human gonadotropins are widely used for induction of ovulation in the treatment of anovulatory infertility and for induction of multiple follicular development (MFD) in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and artificial insemination with husband's semen (AIH) programs. Reported is a patient with normal menstrual cycles, who had two episodes of gonadal unresponsiveness to human gonadotropin therapy, followed by transient hypergonadotropic amenorrhea ("resistant ovary” syndrome), during induction of MFD in conjunction with AIH as treatment for unexplained infertility. The first episode occurred during the sixth cycle of a first series of MFD induction with daily intramuscular injections of exogenous gonadotropins. The second episode occurred during the second cycle of a second series of MFD induction with intravenous pulsatile administration of FSH. On both occasions, normalization of endogenous gonadotropin levels and reappearance of ovulatory cycles occurred spontaneously, after two and three months, respectively. A similar mechanism could occur in the failures of MFD induction observed in IVF programs. Italian Society of Endocrinology (SIE), 1990 Gonadotropins nationallicence amenorrhea nationallicence resistant ovary syndrome nationallicence unexplained infertility nationallicence multiple follicular development nationallicence Mais V. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Melis Gian Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Antinori D. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Paoletti A. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Strigini F. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Guerriero S. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut de Ruggiero A. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Rioretti P. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/9(1990-10-01), 749-752 0391-4097 13:9<749 1990 13 40618 https://doi.org/10.1007/BF03349615 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349615 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mais V. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Melis Gian Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Antinori D. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Paoletti A. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Strigini F. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Guerriero S. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- de Ruggiero A. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Rioretti P. Istituto di Clinica Ostetrica e Ginecologica, Università di Pisa, Via Roma 67, 56100, Pisa, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/9(1990-10-01), 749-752 0391-4097 13:9<749 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer