caa a22 4500 465804217 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03348624 doi (NATIONALLICENCE)springer-10.1007/BF03348624 Plasma C-peptide response to oral glucose load in hyperthyroidism [Elektronische Daten] [Enzo Bonora, V. Manicardi, M. Zenere, P. Moghetti, C. Coscelli, M. Muggeo] Aim of the present study was to evaluate the pancreatic β cell response to oral glucose load in a group of patients with hyperthyroidism. For this purpose plasma C-peptide at fasting and after a 100 g oral glucose load was measured in 8 newly-diagnosed untreated hyperthyroid patients with fasting normoglycemia, and 8 sex-, age-, and weight-matched healthy controls. As compared to healthy subjects, patients with hyperthyroidism showed higher plasma glucose levels (incremental area 5405 ± 742 vs 2729 ± 539 mg/dl × 180 min, p < 0.05), and slightly reduced plasma C-peptide concentrations (incremental area 166 ± 12 vs 182 ± 36 pmol/ml × 180 min, p = NS) following oral glucose load. The ratios between plasma C-peptide and plasma glucose incremental areas were lower in hyperthyroid patients than in controls (3.66 ± 0.85 vs 10.41 ± 3.08, p < 0.05). These data suggest that hyperthyroidism is characterized by a decreased pancreatic β cell response to oral glucose load. Italian Society of Endocrinology (SIE), 1990 Hyperthyroidism nationallicence pancreatic β-cell nationallicence C-peptide nationallicence oral glucose load nationallicence Bonora Enzo Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut Manicardi V. I Divisione di Medicina, Ospedale di Parma, 43100, Parma, Italy aut Zenere M. Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut Moghetti P. Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut Coscelli C. I Divisione di Medicina, Ospedale di Parma, 43100, Parma, Italy aut Muggeo M. Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 555-557 0391-4097 13:7<555 1990 13 40618 https://doi.org/10.1007/BF03348624 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348624 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bonora Enzo Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Manicardi V. I Divisione di Medicina, Ospedale di Parma, 43100, Parma, Italy aut NATIONALLICENCE 700 1- Zenere M. Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Moghetti P. Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut NATIONALLICENCE 700 1- Coscelli C. I Divisione di Medicina, Ospedale di Parma, 43100, Parma, Italy aut NATIONALLICENCE 700 1- Muggeo M. Cattedra di Malattie del Metabolismo, Università di Verona, 37134, Verona, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 555-557 0391-4097 13:7<555 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer