caa a22 4500 46580425X CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03348633 doi (NATIONALLICENCE)springer-10.1007/BF03348633 Bone mineralization and calciotropic hormones in children with hyperthyroidism. Effects of methimazole therapy [Elektronische Daten] [Giuseppe Saggese, S. Bertelloni, G. Baronöelli] We studied bone mineralization and calcium homeostasis in two children with hyperthyroidism before and during 3 yr of methimazole therapy in order to evaluate the effects of thyrotoxicosis and its therapy on mineral metabolism. Case 1, female, 4.1 year old with hyperthyroidism from 6 months. Biochemical data: increased thyroid function, phosphate and osteocalcin, decreased 1,25(OH)2 D levels. X-ray: severe osteoporosis; bone mineral content (BMC) −23.0%, BMC/BW −25.1%. Case 2, female, 7.4 year old with hyperthyroidism from 9 months. Biochemical data: thyroid function, ionized calcium and osteocalcin were increased, 1,25(OH)2 D and intact PTH were decreased. X-ray: severe osteoporosis: BMC −32.8%, BMC/BW −36.0, After the patients were euthyroid, they showed an increase of 1,25(OH)2 D and intact PTH into normal values and a fall in calcium and phosphate. Osteocalcin levels returned in normal range one yr after first evaluation. Bone mineral analysis showed no variation of BMC and BMC/BW in the first 6 months of therapy and an increase in the following 6 months. In the following two years BMC and BMC/BW rose to normal range. Our study provides further evidence that in hyperthyroidism an altered mineral homeostasis is present with a reversible disturbance in vitamin D metabolism. We found that the return to euthyroidism was associated with a normalization of mineral homeostasis and with a recovery of bone mineralization. Osteocalcin assay may be an useful index to monitor bone metabolism in hyperthyroidism. Italian Society of Endocrinology (SIE), 1990 Hyperthyroidism nationallicence bone demineralization nationallicence calciotropic hormones nationallicence osteocalcin nationallicence single photon absorptiometry nationallicence methimazole therapy nationallicence Saggese Giuseppe Istituto di Clinica Pediatrica, Università di Pisa, Via Roma 35, 56100, Pisa, Italy aut Bertelloni S. Istituto di Clinica Pediatrica, Università di Pisa, Via Roma 35, 56100, Pisa, Italy aut Baronöelli G. Istituto di Clinica Pediatrica, Università di Pisa, Via Roma 35, 56100, Pisa, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 587-592 0391-4097 13:7<587 1990 13 40618 https://doi.org/10.1007/BF03348633 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348633 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saggese Giuseppe Istituto di Clinica Pediatrica, Università di Pisa, Via Roma 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Bertelloni S. Istituto di Clinica Pediatrica, Università di Pisa, Via Roma 35, 56100, Pisa, Italy aut NATIONALLICENCE 700 1- Baronöelli G. Istituto di Clinica Pediatrica, Università di Pisa, Via Roma 35, 56100, Pisa, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 587-592 0391-4097 13:7<587 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer