caa a22 4500 465804314 CHVBK 20180323112059.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03348623 doi (NATIONALLICENCE)springer-10.1007/BF03348623 The mechanism of the effect of combination treatment wit clomiphene and bromocriptine in patients with normoprolactinemic anovulation [Elektronische Daten] [Toshiyuki Yasui, M. Irahara, K. Shisukawa, K. Azuma, T. Aono] The combination treatment with bromocriptine and clomiphene citrate was applied to 11 normoprolactinemic anovulatory patients who did not respond to clomiphene citrate alone. This combination treatment restored ovulation in 8 of these patients (72.7%). Conception was observed in 2 patients (18.1%) out of 11. The patients who responded to combination treatment showed a significant increase in the serum level of estradiol in the preovulatory phase, of progesterone in the mid-luteal phase, and a significant decrease of serum prolactin. They also showed significant increase in the frequency of luteinizing hormone (LH) pulsatility on day 12 of the cycle from 1.38 ± 0.86 to 3.75 ± 0.83 pulses /4h. The 3 patients who did not respond to combination treatment showed no increase in the serum level of estradiol or progesterone, but showed increase in the frequency of LH pulsatility in spite of continuous anovulation. These results indicate that the combination treatment with bromocriptine and clomiphene citrate is effective for treatment of patients with normoprolactinemic anovulation who do not respond to clomiphene alone, and suggest that the mechanism of the effect of combination treatment is related to an increase in the frequency of LH pulsatility caused by bromocriptine, which in turn stimulates follicular maturation. Italian Society of Endocrinology (SIE), 1990 Normoprolactinemia nationallicence clomiphene citrate nationallicence bromocriptine nationallicence combination treatment nationallicence LH pulsatility nationallicence Yasui Toshiyuki Department of Obstetrics and Gynecology, The University of Tokushima, Scool of Medicine, 770, Kuramoto-cho, Tokushima, Japan aut Irahara M. aut Shisukawa K. aut Azuma K. aut Aono T. aut Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 549-554 0391-4097 13:7<549 1990 13 40618 https://doi.org/10.1007/BF03348623 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348623 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yasui Toshiyuki Department of Obstetrics and Gynecology, The University of Tokushima, Scool of Medicine, 770, Kuramoto-cho, Tokushima, Japan aut NATIONALLICENCE 700 1- Irahara M. aut NATIONALLICENCE 700 1- Shisukawa K. aut NATIONALLICENCE 700 1- Azuma K. aut NATIONALLICENCE 700 1- Aono T. aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 549-554 0391-4097 13:7<549 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer