caa a22 4500 465804411 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19900701xx s 000 0 eng 10.1007/BF03348622 doi (NATIONALLICENCE)springer-10.1007/BF03348622 Epidemiology and clinical characteristics of endemic cretinism in Sicily [Elektronische Daten] [Francesco Trimarchi, F. Vermiglio, M. Finocchiaro, S. Battiate, V. Lo Presti, N. Torre, F. Calaciura, C. Regalbuto, L. Sava, R. Vigneri] In this study we report the prevalence of endemic cretinism in the general population of two iodine deficient areas in Northeastern Sicily that were described more than 10 yr ago. In addition, the individual characteristics of endemic cretins are considered in order to define the typical expressions of this major iodine deficiency disorder in Sicily. Forty-three mental defectives were identified: 22 were living in an area with three bordering and closely connected municipalities within the province of Messina and with a population of 17,485 inhabitants (prevalence= 0.13%). Three out of the 22 were school-age children. The other community, in the province of Catania, was constituted by a unique and mostly agricultural hamlet, and showed a prevalence of cretinism that was 0.68% (21/3,100). Among the 43 mental defectives, 16 (37%) presented prominent neuromotor and neurosensorial disorders, including deafmutism and were euthyroid, thus conforming to the neurological type of cretinism; 13 (30%) were hypothyroid and exhibited stunted growth without significant neuromotor and neurosensorial impairment (myxedematous cretins). In the remaining 14 individuals (33%) neurological disorders were associated with stunted growth and clinical or biochemical hypothyroidism. These data indicate that also in Sicily endemic cretinism is a continuum of a variety of forms: among these the pure neurological and pure myxedematous forms represent the two extremes.Our observations also indicate that endemic cretinism still represents a major public health problem in Sicily.The finding of 3 endemic cretins younger than 13 yr suggests the persistence of this disorder even in the presence of improved economic, social and nutritional conditions. Italian Society of Endocrinology (SIE), 1990 Iodine deficiency nationallicence iodine deficiency disorders (IDD) nationallicence endemic cretinism nationallicence myxedematous cretinism nationallicence neurological cretinism nationallicence Trimarchi Francesco Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut Vermiglio F. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut Finocchiaro M. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut Battiate S. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut Lo Presti V. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut Torre N. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut Calaciura F. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut Regalbuto C. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut Sava L. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut Vigneri R. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 543-548 0391-4097 13:7<543 1990 13 40618 https://doi.org/10.1007/BF03348622 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03348622 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trimarchi Francesco Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Vermiglio F. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Finocchiaro M. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Battiate S. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Lo Presti V. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Torre N. Istituto Pluridisciplinare di Clinica Medica, Università di Messina, 98100, Messina, Italy aut NATIONALLICENCE 700 1- Calaciura F. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut NATIONALLICENCE 700 1- Regalbuto C. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut NATIONALLICENCE 700 1- Sava L. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut NATIONALLICENCE 700 1- Vigneri R. Cattedra di Endocrinologia e Patologia Costituzionale, Università di Catania, 95100, Catania, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/7(1990-07-01), 543-548 0391-4097 13:7<543 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer