caa a22 4500 465804535 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF03349547 doi (NATIONALLICENCE)springer-10.1007/BF03349547 Long term growth hormone (GH)-releasing hormone and biosynthetic GH therapy in GH-deficient children: comparison of therapeutic effectiveness [Elektronische Daten] [M. Bozzola, I. Biscaldi, M. Cisternino, F. Severi, A. Balsamo, E. Cacciari, C. Pellini, G. Chiumello, G. Spadoni, B. Boscherini, S. Bernasconi, L. Benso, G. Cavagnini, E. Spolettini, F. Antoniazzi, L. Tatò] Twenty-five GH-deficient children were treated with GHRH (1-44), once daily sc for 6-24 months. At the 6th month of therapy, 40% of our patients showed a catch-up growth (responded), while the remaining 60% did not (nonre-sponders). No differences in auxological and biological variables at inclusion were found between the two groups. However, integrated GH secretion elicited by iv GHRH at inclusion was significantly (p<0.025) higher in responders than in non responded. During GHRH therapy, no significant increase in IGF 1/SmC was found in both groups. In all patients treatment was discontinued after 6-24 months, when its effect on growth rate failed. After a wash-out period of at least 6 months, patients were submitted to biosynthetic GH therapy. After 6 months of GH treatment a significant catch-up growth was found in both responder and non-responder children. Although the majority of GH-deficient children have hypothalamic rather than pituitary dysfunction, GHRH therapy is found to be less effective than GH treatment. Other methods of GHRH administration are worth investigating. Italian Society of Endocrinology (SIE), 1990 GHRH therapy nationallicence GH therapy nationallicence GH-deficiency nationallicence Bozzola M. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut Biscaldi I. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut Cisternino M. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut Severi F. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut Balsamo A. Clinica Pediatrica II, Università di Bologna, Italy aut Cacciari E. Clinica Pediatrica II, Università di Bologna, Italy aut Pellini C. Clinica Pediatrica III, Università di Milano, Italy aut Chiumello G. Clinica Pediatrica III, Università di Milano, Italy aut Spadoni G. Clinica Pediatrica II, Università di Roma, Italy aut Boscherini B. Clinica Pediatrica II, Università di Roma, Italy aut Bernasconi S. Clinica Pediatrica, Università di Parma, Italy aut Benso L. Clinica Pediatrica III, Università di Torino, Italy aut Cavagnini G. Centro Auxologico di Piancavallo, Università di Verona, Italy aut Spolettini E. Clinica Pediatrica, Università di Verona, Italy aut Antoniazzi F. Clinica Pediatrica, Università di Verona, Italy aut Tatò L. Clinica Pediatrica, Università di Verona, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/3(1990-03-01), 235-239 0391-4097 13:3<235 1990 13 40618 https://doi.org/10.1007/BF03349547 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349547 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bozzola M. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Biscaldi I. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Cisternino M. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Severi F. Clinica Pediatrica, Università di Pavia, P.le Golgi, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Balsamo A. Clinica Pediatrica II, Università di Bologna, Italy aut NATIONALLICENCE 700 1- Cacciari E. Clinica Pediatrica II, Università di Bologna, Italy aut NATIONALLICENCE 700 1- Pellini C. Clinica Pediatrica III, Università di Milano, Italy aut NATIONALLICENCE 700 1- Chiumello G. Clinica Pediatrica III, Università di Milano, Italy aut NATIONALLICENCE 700 1- Spadoni G. Clinica Pediatrica II, Università di Roma, Italy aut NATIONALLICENCE 700 1- Boscherini B. Clinica Pediatrica II, Università di Roma, Italy aut NATIONALLICENCE 700 1- Bernasconi S. Clinica Pediatrica, Università di Parma, Italy aut NATIONALLICENCE 700 1- Benso L. Clinica Pediatrica III, Università di Torino, Italy aut NATIONALLICENCE 700 1- Cavagnini G. Centro Auxologico di Piancavallo, Università di Verona, Italy aut NATIONALLICENCE 700 1- Spolettini E. Clinica Pediatrica, Università di Verona, Italy aut NATIONALLICENCE 700 1- Antoniazzi F. Clinica Pediatrica, Università di Verona, Italy aut NATIONALLICENCE 700 1- Tatò L. Clinica Pediatrica, Università di Verona, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/3(1990-03-01), 235-239 0391-4097 13:3<235 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer