caa a22 4500 465804578 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF03349543 doi (NATIONALLICENCE)springer-10.1007/BF03349543 The growth hormone response to growth hormone releasing hormone in patients previously treated with bilateral adrenalectomy alone for Cushing's disease [Elektronische Daten] [H. Whitehead, J. McKnight, B. Sheridan, A. Kennedy, D. Hadden, A. Atkinson] Human growth hormone releasing hormone (GHRH) fails to stimulate human growth hormone (GH). in hypercortisolism. In order to study whether the responsiveness to GHRH stimulation returns after cure of the hypercortisolism, the GH response to GHRH was examined in 8 patients at least 5 yr after they had undergone bilateral adrenalectomy as their sole treatment for Cushing's disease. None had current evidence of a pituitary macroadenoma. A group of 8 healthy subjects matched for age and sex formed the control group. All patients and subjects received an iv injection of GHRH 1 μg/kg, after an overnight fast, blood samples were taken before and at 15, 30, 45, 60, 90 and 120 min. There was no statistical difference between the peak GH or area under curve (AUC) response (median, range) in the two groups studied (adrenalectomized peak GH 9.2 (4.6-32.0) vs 16.5 (7.5-63) mU/l, adrenalectomized AUC response 647.5 (344.2-1489.5) vs 1103.5 (339.7-5188.5) mU/l. Patients with Cushing's disease once cured of hypercortisolism, have a GH response to GHRH. Italian Society of Endocrinology (SIE), 1990 Growth hormone nationallicence growth hormone releasing hormone nationallicence hypercortisolism nationallicence Cushing's disease nationallicence bilateral adrenalectomy nationallicence Whitehead H. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut McKnight J. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut Sheridan B. Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast, Northern Ireland aut Kennedy A. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut Hadden D. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut Atkinson A. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut Journal of Endocrinological Investigation Springer International Publishing 13/3(1990-03-01), 217-220 0391-4097 13:3<217 1990 13 40618 https://doi.org/10.1007/BF03349543 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349543 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Whitehead H. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut NATIONALLICENCE 700 1- McKnight J. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut NATIONALLICENCE 700 1- Sheridan B. Regional Endocrine Laboratory, Royal Victoria Hospital, Belfast, Northern Ireland aut NATIONALLICENCE 700 1- Kennedy A. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut NATIONALLICENCE 700 1- Hadden D. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut NATIONALLICENCE 700 1- Atkinson A. Sir George E. Clark Metabolic Unit, Royal Victoria Hospital, Grosvenor Road, BT12 6BA, Belfast, Northern Ireland aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/3(1990-03-01), 217-220 0391-4097 13:3<217 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer