caa a22 4500 465804632 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF03349539 doi (NATIONALLICENCE)springer-10.1007/BF03349539 Thyroid iodine content and serum thyroglobulin level following external irradiation to the neck for Hodgkin's disease [Elektronische Daten] [M. Schlumberger, M. Sebagh, F. De Vathaire, C. Bayle, P. Fragu, C. Parmentier] Fifty-four clinically euthyroid patients were evaluated 1 up to 17 yr after external irradiation to the neck for Hodgkin's disease. T4 level was decreased in 6%, while basal TSH level was increased in 44%, and TSH response to TRH was increased in 66% of the patients with normal basal TSH level. Thyroid iodine content (TIC), measured in 50 patients, was below 5 mg in 18. The 29 patients with normal basal TSH level had a mean TIC (6.8 ± 2.7 mg) significantly lower (p < 0.01) than the control population (14.6 ± 5 mg). A significant positive correlation was found between log T4 and log TIC (r = 0.55, p < 0.01). Thyroglobulin (Tg) level was increased in 53% of the patients with no palpable thyroid abnormality. It was not related to TSH level but was related to younger age at irradiation. T4 treatment decreased Tg level to the normal range in 5 of 8 patients. These facts suggest subclinical thyroid abnormalities and patients with elevated Tg levels should be considered at risk for developing a thyroid tumor. Italian Society of Endocrinology (SIE), 1990 Thyroid gland nationallicence external irradiation nationallicence thyroid iodine content nationallicence thyroglobulin nationallicence Schlumberger M. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut Sebagh M. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut De Vathaire F. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut Bayle C. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut Fragu P. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut Parmentier C. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut Journal of Endocrinological Investigation Springer International Publishing 13/3(1990-03-01), 197-203 0391-4097 13:3<197 1990 13 40618 https://doi.org/10.1007/BF03349539 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349539 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schlumberger M. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut NATIONALLICENCE 700 1- Sebagh M. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut NATIONALLICENCE 700 1- De Vathaire F. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut NATIONALLICENCE 700 1- Bayle C. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut NATIONALLICENCE 700 1- Fragu P. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut NATIONALLICENCE 700 1- Parmentier C. Department of Nuclear Medicine, Institut Gustave-Roussy, 94805, Villejuif Cedex, France aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/3(1990-03-01), 197-203 0391-4097 13:3<197 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer