caa a22 4500 465804659 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF03349636 doi (NATIONALLICENCE)springer-10.1007/BF03349636 A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased nuclear triiodothyronine receptors [Elektronische Daten] [C. Jaffiol, L. Baldet, J. Torresani, J. Bismuth, C. Papachristou] A 52-year-old male presented himself with tachycardia crises which appeared first during childhood, increased in frequency without goiter or exophthalmos. Cardiac and adrenergic diseases were excluded. The thyroid function was normal regarding T4, free T4 and T3, TBG, radioiodine uptake, TSH and T3 suppressibility; however the TSH response to TRH was decreased. The lymphocyte nuclear T3 receptor was found with an affinity close to that of normal volunteers (Ka: 1.42 × 1010 M−1 vs 1.95 ± 0.35 × 1010 M−1) and a binding capacity markedly increased (9.9 vs 3.7 ± 0.4 fmol T3/100 μg DNA). Pindolol was inefficient on the dysrhythmia which disappeared with carbimazole and relapsed after withdrawal of the antithyroid drug. Under carbimazole, the plasma T4 markedly decreased (27.7 ± 3.6 nmol/l) but the patient remained euthyroid. The clinical course and the laboratory data suggest that the tachycardia crises are the consequence of a hypersensitivity of the heart to thyroid hormones, associated with an increased number of T3 nuclear receptor sites in lymphocytes. Italian Society of Endocrinology (SIE), 1990 Hypersensitivity nationallicence thyroid hormones nationallicence T3 nuclear receptors nationallicence Jaffiol C. Service d'Endocrinologie, Hôpital Lapeyronie, 34059, Montpellier Cedex, France aut Baldet L. Service d'Endocrinologie, Hôpital Lapeyronie, 34059, Montpellier Cedex, France aut Torresani J. Laboratoire de Biochimie Medicale et groupe U38 INSERM, Faculte de Medecine, 13385, Marseille Cedex 5, France aut Bismuth J. Laboratoire de Biochimie Medicale et groupe U38 INSERM, Faculte de Medecine, 13385, Marseille Cedex 5, France aut Papachristou C. Service d'Endocrinologie, Hôpital Lapeyronie, 34059, Montpellier Cedex, France aut Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 839-845 0391-4097 13:10<839 1990 13 40618 https://doi.org/10.1007/BF03349636 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349636 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jaffiol C. Service d'Endocrinologie, Hôpital Lapeyronie, 34059, Montpellier Cedex, France aut NATIONALLICENCE 700 1- Baldet L. Service d'Endocrinologie, Hôpital Lapeyronie, 34059, Montpellier Cedex, France aut NATIONALLICENCE 700 1- Torresani J. Laboratoire de Biochimie Medicale et groupe U38 INSERM, Faculte de Medecine, 13385, Marseille Cedex 5, France aut NATIONALLICENCE 700 1- Bismuth J. Laboratoire de Biochimie Medicale et groupe U38 INSERM, Faculte de Medecine, 13385, Marseille Cedex 5, France aut NATIONALLICENCE 700 1- Papachristou C. Service d'Endocrinologie, Hôpital Lapeyronie, 34059, Montpellier Cedex, France aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 839-845 0391-4097 13:10<839 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer