caa a22 4500 465804667 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF03349622 doi (NATIONALLICENCE)springer-10.1007/BF03349622 Resistance to insulin suppression of plasma free fatty acids in liver cirrhosis [Elektronische Daten] [M. Merli, F. Leonetti, O. Riggio, A. Giaccari, A. Romiti, P. Sbraccia, G. Tamburrano] Insulin action on carbohydrate metabolism is known to be reduced in liver cirrhosis. However, little is known about the effect of insulin on free fatty acid (FFA) metabolism in these patients. To investigate this aspect we performed a two-step insulin euglycemic clamp in 11 cirrhotic patients and 6 controls. Insulin was infused at 0.25 mU/Kg min from 0 to 100 min and at 1 mU/Kg from 100 to 200 min. The FFA lowering capacity of insulin was studied during the first step; the glucose metabolizing capacity (M) was evaluated during the second step. In the cirrhotic patients, the M value was lower than in controls (3.91±0.48 vs 7.75±1.09 mg/kg/min, respectively). During the low insulin infusion, FFA and glycerol plasma levels were decreased in both groups. However, the ability of insulin to suppress plasma FFA and glycerol was lower in cirrhotics than in controls. In fact, at 100 min, FFA were 50% of basal values in cirrhotics and 20% in controls (p<0.01), while glycerol plasma levels decreased to 70% of basal values in patients and to 56% in controls. The slope of the linear regression obtained between Ln-FFA concentrations vs time was significantly less in cirrhotic patients than in controls (p<0.001). In addition, a positive correlation was found between the M value (r = 0.70; p<0.01) and the slope of the Ln-FFA in each patient. These findings suggest that in cirrhotic patients the effects of insulin on both FFA and glucose metabolism are reduced. Italian Society of Endocrinology (SIE), 1990 Cirrhosis nationallicence free fatty acids nationallicence insulin resistance nationallicence glucose metabolism nationallicence lipolysis nationallicence Merli M. 2° Gastroenterologia, Ist. di Clinica Medica III, Viale dell'Università 37, 00161, Roma, Italy aut Leonetti F. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut Riggio O. Dipartimento di Medicina interna, University of L'Aquila, San Sisto, 67100, L'Aquila, Italy aut Giaccari A. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut Romiti A. 2° Gastroenterologia, Ist. di Clinica Medica III, Viale dell'Università 37, 00161, Roma, Italy aut Sbraccia P. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut Tamburrano G. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 787-795 0391-4097 13:10<787 1990 13 40618 https://doi.org/10.1007/BF03349622 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349622 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merli M. 2° Gastroenterologia, Ist. di Clinica Medica III, Viale dell'Università 37, 00161, Roma, Italy aut NATIONALLICENCE 700 1- Leonetti F. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut NATIONALLICENCE 700 1- Riggio O. Dipartimento di Medicina interna, University of L'Aquila, San Sisto, 67100, L'Aquila, Italy aut NATIONALLICENCE 700 1- Giaccari A. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut NATIONALLICENCE 700 1- Romiti A. 2° Gastroenterologia, Ist. di Clinica Medica III, Viale dell'Università 37, 00161, Roma, Italy aut NATIONALLICENCE 700 1- Sbraccia P. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut NATIONALLICENCE 700 1- Tamburrano G. 1° Endocrinologia, University "La Sapienza”, 00161, Roma, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 787-795 0391-4097 13:10<787 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer