caa a22 4500 465804683 CHVBK 20180323112100.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF03349629 doi (NATIONALLICENCE)springer-10.1007/BF03349629 Gangliosides and phospholipids in human thyroids responsive and unresponsive to thyrotropin [Elektronische Daten] [A. Mariano, A. Di Carlo, P. Macchia, G. Pisano, U. Parmeggiani, Vincenzo Macchia] The patterns of gangliosides and phospholipids and their relation to TSH response were examined in twenty-six malignant thyroid tumors (4 follicular, 6 papillary, 5 medullary, 11 anaplastic carcinomas) and thirty-six hyperplastic goiters. Thirteen thyroid tissues adjacent to benign tumors with no evidence of macroscopic or microscopic abnormalities were used as normal tissue. In normal thyroids the major ganglioside was GD3 (44%) and GM3 was the second ganglioside (20%). In minor amounts GD1a (8.6%), GD1b (6.2%), GT1b (5.7%) and GM1 (5.6%) were present. In hyperplastic goiters and in follicular carcinomas the patterns of gangliosides were similar to that of normal tissue except for GM3 which, in the last tissue, was higher (34%). In papillary carcinomas low levels of GM3 (11%) and GT1b (0.8%) with a high level of GD1b (12.6%) were found. In anaplastic carcinomas GM3 was very high (47%) whereas GD3 was low (18%). In these tumors also a high percentage (14.0%) of GD1a was found. In medullary carcinomas the lowest levels of GM3 (4%) with the highest level of GD3 (64%) were found. Although large differences of the gangliosides distribution were clearly encountered in the various pathological human thyroid, no correlation between lack of TSH response and some individual ganglioside could be made. No differences in the individual phospholipid in the various tissues studied were found. Italian Society of Endocrinology (SIE), 1990 Gangliosides nationallicence phospholipids nationallicence TSH-response nationallicence thyroid tumors nationallicence Mariano A. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut Di Carlo A. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut Macchia P. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut Pisano G. Cattedra di Endocrinologia, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut Parmeggiani U. Cattedra di Chirurgia, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut Macchia Vincenzo Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 817-823 0391-4097 13:10<817 1990 13 40618 https://doi.org/10.1007/BF03349629 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349629 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mariano A. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Di Carlo A. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Macchia P. Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Pisano G. Cattedra di Endocrinologia, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Parmeggiani U. Cattedra di Chirurgia, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Macchia Vincenzo Centro di Endocrinologia ed Oncologia Sperimentale del C.N.R. e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, University of Napoli, via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 817-823 0391-4097 13:10<817 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer