caa a22 4500 465804713 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF03349632 doi (NATIONALLICENCE)springer-10.1007/BF03349632 Two cases of Graves' disease with antithyroid hormone antibodies: Implication on the role of thyroglobulin as an antigen [Elektronische Daten] [S. Sakata, K. Nagai, O. Tarutani, Y. Kohno, K. Saito, T. Komaki, H. Takuno, M. Matsuda, T. Ogawa, N. Tokimitsu, K. Miura] We have experienced two cases of Graves' disease with antithyroid hormone autoantibodies (Case 1: anti-T4; Case 2: anti-T3) who finally underwent subtotal thyroidectomy after antithyroid drug treatment. Using serial sera obtained before and after operation, the correlation between titers of antithyroglobulin (anti-Tg) and anti-T4 or anti-T3 autoantibodies was examined in each case. There was a significant positive correlation between titers of anti-T4 (Case 1, r = 0.90, p < 0.05), or anti-T3 (Case 2, r = 0.64, p < 0.01) and anti-Tg antibodies. Using the homogenate of the thyroid tissue, it was found that the sole iodoprotein in the thyroid gland in each patient was 660 KDa Tg. In addition, Tg purified from the thyroid gland from Case 2 showed different immunological activity with normal Tg in two out of four murine monoclonal anti-Tg antibodies tested. On the other hand, Tg from Case 1 had identical immunological activity with normal Tg in every four monoclonal antibodies. These results are consistent with the view that the antigen responsible for the development of antithyroid hormone autoantibodies is Tg, at least in our two cases. The reason for the persistence of anti-T3 autoantibodies in Case 2, despite the subtotal thyroidectomy, could be due to some unidentified structural abnormalities of Tg which was detected only by the monoclonal anti-Tg antibodies. Italian Society of Endocrinology (SIE), 1990 Graves' disease nationallicence antithyroid hormone antibodies nationallicence antigen nationallicence thyroglobulin nationallicence antithyroglobulin antibodies nationallicence Sakata S. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut Nagai K. Department of Internal Medicine, Takayama Red Cross Hospital, 506, Takayama, Japan aut Tarutani O. Division of Biological Chemistry, Science University of Tokyo, 278, Noda, Japan aut Kohno Y. Department of Pediatrics, Chiba University School of Medicine, 280, Chiba, Japan aut Saito K. Department of Pediatrics, Chiba University School of Medicine, 280, Chiba, Japan aut Komaki T. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut Takuno H. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut Matsuda M. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut Ogawa T. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut Tokimitsu N. Department of Internal Medicine, Takayama Red Cross Hospital, 506, Takayama, Japan aut Miura K. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 825-832 0391-4097 13:10<825 1990 13 40618 https://doi.org/10.1007/BF03349632 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349632 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sakata S. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut NATIONALLICENCE 700 1- Nagai K. Department of Internal Medicine, Takayama Red Cross Hospital, 506, Takayama, Japan aut NATIONALLICENCE 700 1- Tarutani O. Division of Biological Chemistry, Science University of Tokyo, 278, Noda, Japan aut NATIONALLICENCE 700 1- Kohno Y. Department of Pediatrics, Chiba University School of Medicine, 280, Chiba, Japan aut NATIONALLICENCE 700 1- Saito K. Department of Pediatrics, Chiba University School of Medicine, 280, Chiba, Japan aut NATIONALLICENCE 700 1- Komaki T. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut NATIONALLICENCE 700 1- Takuno H. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut NATIONALLICENCE 700 1- Matsuda M. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut NATIONALLICENCE 700 1- Ogawa T. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut NATIONALLICENCE 700 1- Tokimitsu N. Department of Internal Medicine, Takayama Red Cross Hospital, 506, Takayama, Japan aut NATIONALLICENCE 700 1- Miura K. The Third Department of Internal Medicine, Gifu University School of Medicine, 500, Gifu, Japan aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 825-832 0391-4097 13:10<825 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer