caa a22 4500 46580473X CHVBK 20180323112101.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF03349626 doi (NATIONALLICENCE)springer-10.1007/BF03349626 Evaluation of Clonidine suppression and various provocation tests in the diagnosis of pheochromocytoma [Elektronische Daten] [H. Koshida, I. Miyamori, R. Soma, T. Matsubara, S. Okamoto, M. Ikeda, R. Takeda] Recent investigations have shown that the widely used Clonidine suppression test is sometimes fallible for the diagnosis of pheochromocytoma. A comparative assessment was made of the following suppression and provocation tests, the Clonidine suppression test, and the glucagon, metoclopramide, and naloxone provocation tests. The assessment was performed in 6 patients with pheochromocytoma and in 19 patients without pheochromocytoma who were initially suspected of harboring a tumor. BP response did not predict the presence of pheochromocytoma in any test. Plasma norepinephrine (NE) concentrations determined at 120 and 180 min after oral 150 μg of Clonidine gave false negative results in 2 of the 5 patients with pheochromocytoma tested. Both plasma NE and epinephrine (E) concentrations were measured before and sequentially after each provocative agent. Neither NE nor E responded to 1 mg of glucagon iv in 2 of the 4 patients with pheochromocytoma tested. Determination of the peak level, peak increment, and % peak increment of NE and E following 10 mg of naloxone iv did not distinguish the two groups. The % peak increments of both NE and E in all 4 patients with pheochromocytoma given 5 mg of metoclopramide iv exceeded the mean + 3 SD values of the patients without pheochromocytoma (25 + 28% for NE, and 25 + 42% for E). These results suggested that, when performed with judicious patient selection (ambiguous plasma or urinary catecholamine levels), the measurement of plasma catecholamines in response to metoclopramide can be a useful adjunctive tool in the diagnosis of pheochromocytoma. Italian Society of Endocrinology (SIE), 1990 Koshida H. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Miyamori I. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Soma R. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Matsubara T. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Okamoto S. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Ikeda M. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Takeda R. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 807-815 0391-4097 13:10<807 1990 13 40618 https://doi.org/10.1007/BF03349626 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349626 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koshida H. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Miyamori I. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Soma R. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Matsubara T. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Okamoto S. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Ikeda M. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 700 1- Takeda R. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Takara-machi 13-1, 920, Kanazawa, Japan aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 807-815 0391-4097 13:10<807 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer