caa a22 4500 465804810 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19901101xx s 000 0 eng 10.1007/BF03349640 doi (NATIONALLICENCE)springer-10.1007/BF03349640 Hypogonadotropic hypogonadism in idiopathic hemochromatosis: evidence for combined hypothalamic and pituitary involvement [Elektronische Daten] [K. Siminoski, M. D'Costa, P. Walfish] Hypogonadism is a common finding in idiopathic hemochromatosis. Most studies have localized the defect to either the pituitary gland or the testes. We describe a case with evidence that favors the likely concomitant involvement of the hypothalamus as a factor in the observed hypogonadism. A clinically hypogonadal male with hemochromatosis had a low testosterone concentration with inappropriately normal serum LH levels. Leydig cell function was intact, as demonstrated by a normal increase in serum testosterone following HCG administration. However, although the pituitary secretion of LH was normal in response to GnRH stimulation, clomiphene administration did not produce an increase in LH and FSH, suggesting that there was a defect in the hypothalamic GnRH response. Since the FSH and prolactin responses to stimulatory testing were inadequate, coexisting pituitary dysfunction was likely also present. We conclude that this man had hypogonadism with laboratory evidence for a combined defect in hypothalamic and pituitary function. Italian Society of Endocrinology (SIE), 1990 Hemochromatosis nationallicence hypogonadism nationallicence hypothalamic and pituitary nationallicence clomiphene and GnRH testing nationallicence Siminoski K. Department of Medicine, Division of Endocrinology, Room 781, Mount Sinai Hospital, M5G 1X5, Toronto, Ontario, Canada aut D'Costa M. Department of Clinical Biochemistry, Mount Sinai Hospital and Medical School, University of Toronto, Toronto, Canada aut Walfish P. Department of Medicine, Division of Endocrinology, Room 781, Mount Sinai Hospital, M5G 1X5, Toronto, Ontario, Canada aut Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 849-853 0391-4097 13:10<849 1990 13 40618 https://doi.org/10.1007/BF03349640 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349640 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Siminoski K. Department of Medicine, Division of Endocrinology, Room 781, Mount Sinai Hospital, M5G 1X5, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- D'Costa M. Department of Clinical Biochemistry, Mount Sinai Hospital and Medical School, University of Toronto, Toronto, Canada aut NATIONALLICENCE 700 1- Walfish P. Department of Medicine, Division of Endocrinology, Room 781, Mount Sinai Hospital, M5G 1X5, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/10(1990-11-01), 849-853 0391-4097 13:10<849 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer