caa a22 4500 46580490X CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349564 doi (NATIONALLICENCE)springer-10.1007/BF03349564 Long-term observation of endocrine ophthalmopathy and retrospective appraisal of therapeutic measures [Elektronische Daten] [G. Kahaly, H. Böckmann, J. Beyer, S. Bischoff] The course of endocrine ophthalmopathy was investigated on the basis of clinical and biochemical parameters and in relation to different therapeutic strategies. A retrospective appraisal was made of 297 patients (44 ± 14 yr, 249 women) with inclusion of anamnestic and clinical data as well as the results of computer tomography. At the beginning of therapy, 253 patients were hyperthyroid, 36 were euthyroid and eight were hypothyroid. The HLA typing carried out in 89 patients showed the phenotypes B8 and DR3 in 32% and 42% of the cases, respectively. Raised microsomal antibodies were present in 56% of the patients and there were raised thyroglobulin antibodies in 19%. Sixty-three % of the patients received immu-nosuppressants in the course of therapy: glucocorticoids in all cases, nonsteroid immunosuppressants in 15%. Eight % of the patients were irradiated retrobulbarly. The inflammatory parameters could be favorably affected, whereas eye muscle involvement and bulbar protrusion proved to be more resistant to therapy. In patients with combined immunosuppressant therapy or steroids + retrobulbar radiation, there were unequivocal successes with regard to the proptosis, vision and intraocular pressure. None of the strategies applied constitutes an optimal treatment with regard to the long-term course. Following therapy, there is an improvement of endocrine ophthalmopathy, but not complete healing. Italian Society of Endocrinology (SIE), 1990 Long-term observation nationallicence ophthalmopathy nationallicence retrospective appraisal nationallicence therapy nationallicence Kahaly G. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut Böckmann H. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut Beyer J. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut Bischoff S. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 287-292 0391-4097 13:4<287 1990 13 40618 https://doi.org/10.1007/BF03349564 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349564 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kahaly G. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut NATIONALLICENCE 700 1- Böckmann H. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut NATIONALLICENCE 700 1- Beyer J. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut NATIONALLICENCE 700 1- Bischoff S. III Department of Medicine, Endocrinology and Metabolism, Johannes Gutenberg University Hospital, Langenbeckstr. 1, D-6500, Mainz, FRG aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 287-292 0391-4097 13:4<287 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer