caa a22 4500 465804942 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349570 doi (NATIONALLICENCE)springer-10.1007/BF03349570 Cushing's syndrome with intermittent ectopic ACTH production [Elektronische Daten] [A. van Coevorden, E. Laurent, F. Rickaert, O. van Reeth, E. Van Cauter, J. Mockel] A case of ectopic ACTH syndrome with intermittent secretion in a 72-yr-old woman is described. Plasma and urinary Cortisol levels were obtained at frequent intervals for a period of more than 10 months and varied erratically from the normal range to extremely high values. Nonsuppression by high doses of dexamethasone was documented during a period of hypersecretion. Normal circadian rhythmicity and normal responses to hypoglycemia were observed during an interval of dormance of the ectopic secretion. Hypokalemia did not develop. These findings, together with the occult nature of the primary tumor, resulted in unusual diagnostic difficulties. Liver masses were detected by echography and CT scan. Pathological examination of liver biopsies suggested a neuroendocrine tumor of foregut origin. While a multicentric primary apudoma secreting ACTH was a putative diagnosis, detailed and extensive microscopic post-mortem studies revealed a more likely primary tumor site in the pancreatic tail. Italian Society of Endocrinology (SIE), 1990 van Coevorden A. Department of Endocrinology, Free University of Brussels, Belgium aut Laurent E. Institute of Interdisciplinary Research, Campus Erasme, Bât C., Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium aut Rickaert F. Department of Pathology, Free University of Brussels, Belgium aut van Reeth O. Laboratory of Neuropathology and Neuropeptides Research, Campus Erasme, Free University of Brussels, Belgium aut Van Cauter E. Department of Medicine, The University of Chicago, Illinois, USA aut Mockel J. Department of Endocrinology, Free University of Brussels, Belgium aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 317-326 0391-4097 13:4<317 1990 13 40618 https://doi.org/10.1007/BF03349570 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349570 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Coevorden A. Department of Endocrinology, Free University of Brussels, Belgium aut NATIONALLICENCE 700 1- Laurent E. Institute of Interdisciplinary Research, Campus Erasme, Bât C., Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium aut NATIONALLICENCE 700 1- Rickaert F. Department of Pathology, Free University of Brussels, Belgium aut NATIONALLICENCE 700 1- van Reeth O. Laboratory of Neuropathology and Neuropeptides Research, Campus Erasme, Free University of Brussels, Belgium aut NATIONALLICENCE 700 1- Van Cauter E. Department of Medicine, The University of Chicago, Illinois, USA aut NATIONALLICENCE 700 1- Mockel J. Department of Endocrinology, Free University of Brussels, Belgium aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 317-326 0391-4097 13:4<317 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer