caa a22 4500 465804950 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349560 doi (NATIONALLICENCE)springer-10.1007/BF03349560 Acute beta-blockade changes the extracellular distribution of thyroid hormones [Elektronische Daten] [L. Kayser, H. Perrild, P. Petersen, L. Skovsted, J. Hansen] The acute (within hours) changes in the concentrations of T4, T3, reverse-T3 (rT3) and T3 resin uptake test (T3RU) were studied in 31 hyperthyroid patients for 4 h after po treatment with either acebutolol, Oxprenolol, pindolol or timolol. In 21 of the patients, the changes were compared to changes in the serum concentrations of α 2-macroglobulin (a macromoleculë) and two middle-sized molecules; thyroid hormone-binding globulin (TBG) and albumin in order to calculate the changes in extracellular distribution of the thyroid hormones and to distinguish between changes due to a changed metabolism and changes due to a changed distribution of the thyroid hormones. Acebutolol, Oxprenolol and timolol caused a decrease in serum T3 after 1/2 h, and acebutolol and Oxprenolol also a decrease in rT3 after 1/2-1 h, the changes reversed within 2 h. A concomitant decrease in serum albumin and TBG suggests a change in the extracellular distribution of middlesized molecules to which thyroid hormones are attached, as an explanation of the acute decrease (1 h) of the thyroid hormones. The small and insignificant change in α 2-macroglobulin indicates that the changes are mainly extravascular, but the difference of α 2-macroglobulin changes between the drugs (acebutolol/timolol vs pindolol/oxprenolol) could depend on the intrinsic sympathomimetic activity of the drugs. Italian Society of Endocrinology (SIE), 1990 Thyroid nationallicence beta-adrenergic blockade nationallicence albumin nationallicence α 2-macroglobulin nationallicence acute changes nationallicence Kayser L. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut Perrild H. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut Petersen P. Department of Clinical Chemistry, Odense Hospital, 5000, Odense C, Denmark aut Skovsted L. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut Hansen J. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 277-281 0391-4097 13:4<277 1990 13 40618 https://doi.org/10.1007/BF03349560 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349560 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kayser L. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut NATIONALLICENCE 700 1- Perrild H. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut NATIONALLICENCE 700 1- Petersen P. Department of Clinical Chemistry, Odense Hospital, 5000, Odense C, Denmark aut NATIONALLICENCE 700 1- Skovsted L. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut NATIONALLICENCE 700 1- Hansen J. Department of Internal Medicine and Endocrinology F, Herlev hospital, 2730, Herlev, Denmark aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 277-281 0391-4097 13:4<277 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer