caa a22 4500 465804985 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349565 doi (NATIONALLICENCE)springer-10.1007/BF03349565 Epidermal growth factor receptor and thyrotropin response in human thyroid tissues [Elektronische Daten] [A. Di Carlo, A. Mariano, G. Pisano, U. Parmeggiani, L. Beguinot, V. Macchia] The content of epidermal-growth-factor receptor (EGFr) and its relation to TSH-response were examined in 27 malignant thyroid tumors (5 follicular, 6 papillary, 5 medullary, 11 anaplastic carcinomas) and in 30 tumor-like lesions (21 hyperplastic goiters and 9 toxic adenomatous goiters). Normal 12 thyroid tissues adjacent to benign tumors with no evidence of macroscopic or microscopic abnormalities were used as control. All thyroid plasma membranes tested showed specific EGF binding. In membranes from toxic adenomas (2.18 ± 0.73 fmoles/mg protein) and papillary carcinomas (2.80 ± 0.80) the EGF binding was similar to that of normal thyroid membranes (2.32 ± 0.73). Hyperplastic goiters showed an EGF binding (4.4 ± 0.82) slightly higher than normal tissue. The highest and the lowest EGF binding values were found in anaplastic (11.8 ± 2.78) and medullary (0.50 ± 0.39) carcinomas, respectively. An inverse correlation between EGFr content and TSH-response was found when anaplastic thyroid tumors were compared to tumorlike lesions. However no correlation was observed in medullary carcinomas which also failed to respond to TSH and in papillary carcinomas which partially respond to thyrotropin. Italian Society of Endocrinology (SIE), 1990 EGFr nationallicence TSH nationallicence cAMP nationallicence thyroid nationallicence phosphatidylinositol nationallicence phospholipids nationallicence Di Carlo A. Centro di Endocrinología ed Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, Via Sergio Pansini 5, 80131, Napoli, Italy aut Mariano A. Centro di Endocrinología ed Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, Via Sergio Pansini 5, 80131, Napoli, Italy aut Pisano G. Cattedra di Endocrinologia, Università di Napoli, Napoli, Italy aut Parmeggiani U. Cattedra di Chirurgia, Facoltà di Medicina e Chirurgia, Università di Napoli, Napoli, Italy aut Beguinot L. Institute of Microbiology, University of Copenhagen, Copenhagen, Denmark aut Macchia V. Centro di Endocrinología ed Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, Via Sergio Pansini 5, 80131, Napoli, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 293-299 0391-4097 13:4<293 1990 13 40618 https://doi.org/10.1007/BF03349565 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349565 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Di Carlo A. Centro di Endocrinología ed Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, Via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Mariano A. Centro di Endocrinología ed Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, Via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Pisano G. Cattedra di Endocrinologia, Università di Napoli, Napoli, Italy aut NATIONALLICENCE 700 1- Parmeggiani U. Cattedra di Chirurgia, Facoltà di Medicina e Chirurgia, Università di Napoli, Napoli, Italy aut NATIONALLICENCE 700 1- Beguinot L. Institute of Microbiology, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Macchia V. Centro di Endocrinología ed Oncologia Sperimentale del CNR e Dipartimento di Biologia e Patologia Cellulare e Molecolare, II Facoltà di Medicina e Chirurgia, Via Sergio Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 293-299 0391-4097 13:4<293 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer