caa a22 4500 465805000 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349563 doi (NATIONALLICENCE)springer-10.1007/BF03349563 Autoimmune thyroid disease in the puerperium. Predictive value of thyroid enlargement and related hormonal changes occurring during pregnancy [Elektronische Daten] [C. Fardella, J. López, M. Valdés, M. Nuñez, M. Miranda] The incidence of goiter detected during pregnancy and its significance as an indicator of autoimmune thyroid disease after delivery was investigated in a sample of 707 pregnant women (81% in their 2nd trimester of gestation). Goiter was detected in 106 subjects (15%). Blood T4, T3, TSH, free T4 index (FT4I), antimicrosomal antibodies (AMA) and urinary iodine excretion were measured in these women and in a control group of gravidas without goiter. These measurements were repeated at 1 and 3 months after delivery. Compared with controls during pregnancy, subjects with goiter had lower FT4I values (11.0 ± 2.8 vs 9.0 ± 1.8; p < 0.01) and higher TSH values (2.9 ± 0.6 μU/ml vs 4.2 ± 2.1 μU/ml; p < 0.01). In contrast, T4, T3, AMA and urinary iodine excretion values were similar in both groups. In subjects with goiter FT4I values increased over pregnancy levels at 1 month (11.2 ± 2.0; p < 0.05) and 3 months (14.0 ± 3.0; p < 0.05) after delivery; in 29% a biochemical hyperthyroidism (FT4I > 13.5) was detected. During the same period TSH values decreased significantly (1 month: 1.9 ± 0.7 μU/ml; p < 0.05; 3 months: 2.7 ± 3.0 μU/ml; p < 0.05). Frequency of positive AMA increased from 8.6% during pregnancy up to 32.1% in the post-delivery period (p < 0.01). In the control group no variation in the FT4I, TSH or AMA were observed after delivery. These results indicate that goiter during pregnancy is common in Chilean gravidas and that it has predictive value for the appearance of autoimmune thyroid disease after delivery. Italian Society of Endocrinology (SIE), 1990 Goiter nationallicence pregnancy nationallicence antithyroid antibodies nationallicence post-partum thyroiditls nationallicence Fardella C. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut López J. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut Valdés M. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut Nuñez M. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut Miranda M. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 283-286 0391-4097 13:4<283 1990 13 40618 https://doi.org/10.1007/BF03349563 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349563 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fardella C. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut NATIONALLICENCE 700 1- López J. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut NATIONALLICENCE 700 1- Valdés M. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut NATIONALLICENCE 700 1- Nuñez M. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut NATIONALLICENCE 700 1- Miranda M. Department of Endocrinology, Metabolism and Nutrition, and Obstetric Unit, Pontificia Universidad Católica de Chile, Casilla 114-D, Santiago, Chile aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 283-286 0391-4097 13:4<283 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer