caa a22 4500 465805043 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349567 doi (NATIONALLICENCE)springer-10.1007/BF03349567 Immunohistochemical localization of growth hormone-releasing hormone in human gonads [Elektronische Daten] [C. Moretti, A. Fabbri, L. Gnessi, V. Bonifacio, M. Bolotti, M. Arizzi, Q. Nazzicone, G. Spera] Human gonads were examined for the presence of ir growth hormone-releasing-hormone. We demonstrated the presence of immu-nostainable cells both in ovarian and in testicular tissue using a non-crossreactive antiGRH antiserum and the immunoperoxidase detection technique. In ovaries from ovulating women, GRH immunoreactivity was localized in the corpórea lutea; granulosa cells, theca cells and cells of primary follicles did not stain. In premenopausal ovaries, staining was detectable in scattered luteinized stromal cells. In testes from post-puberal men GRH immunoreactivity was localized in the Leyding cells; cells of the germinal epithelium did not stain. These results demonstrate the presence of GRH in human gonads and suggest that this peptide may exert regulatory function at the testicular and ovarian levels. Italian Society of Endocrinology (SIE), 1990 GRH nationallicence testis nationallicence ovary nationallicence Moretti C. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut Fabbri A. Cattedra di Andrologia, Università degli Studi di Roma "La Sapienza”, Italy aut Gnessi L. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut Bonifacio V. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut Bolotti M. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut Arizzi M. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut Nazzicone Q. Divisione I Ostetricia e Ginecologia, Ospedale San Camillo, Roma, Italy aut Spera G. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 301-305 0391-4097 13:4<301 1990 13 40618 https://doi.org/10.1007/BF03349567 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349567 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moretti C. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Fabbri A. Cattedra di Andrologia, Università degli Studi di Roma "La Sapienza”, Italy aut NATIONALLICENCE 700 1- Gnessi L. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Bonifacio V. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Bolotti M. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Arizzi M. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut NATIONALLICENCE 700 1- Nazzicone Q. Divisione I Ostetricia e Ginecologia, Ospedale San Camillo, Roma, Italy aut NATIONALLICENCE 700 1- Spera G. Clinica Medica V, Università degli Studi di Roma "La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 301-305 0391-4097 13:4<301 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer