caa a22 4500 465805078 CHVBK 20180323112101.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349571 doi (NATIONALLICENCE)springer-10.1007/BF03349571 Hyperthyroidism and hypothyroidism in monozygotic twins: Detection of stimulating and blocking THS receptor antibodies using the FRTL5-cell line [Elektronische Daten] [A. Ilicki, C. Marcus, F. Karlsson] We present a rare history of monozygotic twin girls who at the age of 10 yr presented with hyper- and hypothyroidism, respectively. Both girls had antibodies against thyrotropin receptors as measured by a radioreceptor assay (230 U/l and 1400 U/l; reference range < 7 U/l). The sera were further examined in a bioassay, based on a ratthyroid cell line(FRTL5), in which release of cAMP into medium was measured. The TSH receptor anti-bodies of the hyperthyroid twin displayed a ratio of radioreceptor to biological activity typical of Graves' disease. In contrast, the antibodies of the hypothyroid twin acted as pure antagonists at the TSH receptor level. The occurrence of TSH receptor antibodies in these monozygotic twins suggests a similar pathogenesis of Graves' disease and that of hypothyroidism due to thyroid blocking antibodies. Italian Society of Endocrinology (SIE), 1990 Stimulating and blocking TSH-receptor antibodies nationallicence Graves' disease nationallicence hypothyroidism nationallicence FRTL5-cells nationallicence Ilicki A. Departments of Paediatrics, University Hospital, Uppsala University, S-751 85, Uppsala, Sweden aut Marcus C. Karolinska Institutet, Huddinge Sjukhus, Stockholm, Sweden aut Karlsson F. Department of Internal Medicine, University Hospital, Uppsala, Sweden aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 327-331 0391-4097 13:4<327 1990 13 40618 https://doi.org/10.1007/BF03349571 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349571 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ilicki A. Departments of Paediatrics, University Hospital, Uppsala University, S-751 85, Uppsala, Sweden aut NATIONALLICENCE 700 1- Marcus C. Karolinska Institutet, Huddinge Sjukhus, Stockholm, Sweden aut NATIONALLICENCE 700 1- Karlsson F. Department of Internal Medicine, University Hospital, Uppsala, Sweden aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 327-331 0391-4097 13:4<327 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer