caa a22 4500 465805094 CHVBK 20180323112102.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF03349575 doi (NATIONALLICENCE)springer-10.1007/BF03349575 T cell receptor phenotypes in autoimmune thyroid disease [Elektronische Daten] [W. Teng, S. Cohen, D. Posnett, A. Weetman] We have examined T cell receptor expression by peripheral blood and thyroidal lymphocytes in Graves' disease and Hashimoto's thyroidits, using monoclonal antibodies directed against three β chain variable region families and against the γ chain. There was no abnormal distribution of positive staining with the β chain reagents (compared to normal peripheral blood) in either the thyroid or the blood. However, thyroidal lymphocytes contained an excess of γ-chain-bear-ing T cells, compared to peripheral blood, in five of the seven patients in whom simultaneous samples were available. The γ-chain-positive T cells were not altered in the blood lymphocyte population of untreated Graves' patients. These results suggest that the T cell response in autoimmune thyroid disease is polyclonal and that there may be a role (such as cytotoxicity) for T cells expressing the γδ type of T cell receptor in thyroiditis. Italian Society of Endocrinology (SIE), 1990 T cell receptor nationallicence Graves' disease nationallicence Hashimoto's thyroiditis nationallicence Teng W. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital (Level 5), CB2 2QQ, Cambridge, UK aut Cohen S. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital (Level 5), CB2 2QQ, Cambridge, UK aut Posnett D. Department of Medicine, Division of Allergy and Immunology, The New York Hospital — Cornell Medical Centre, 10021, New York, NY, USA aut Weetman A. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital (Level 5), CB2 2QQ, Cambridge, UK aut Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 339-342 0391-4097 13:4<339 1990 13 40618 https://doi.org/10.1007/BF03349575 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF03349575 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Teng W. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital (Level 5), CB2 2QQ, Cambridge, UK aut NATIONALLICENCE 700 1- Cohen S. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital (Level 5), CB2 2QQ, Cambridge, UK aut NATIONALLICENCE 700 1- Posnett D. Department of Medicine, Division of Allergy and Immunology, The New York Hospital — Cornell Medical Centre, 10021, New York, NY, USA aut NATIONALLICENCE 700 1- Weetman A. Department of Medicine, University of Cambridge Clinical School, Addenbrooke's Hospital (Level 5), CB2 2QQ, Cambridge, UK aut NATIONALLICENCE 773 0- Journal of Endocrinological Investigation Springer International Publishing 13/4(1990-04-01), 339-342 0391-4097 13:4<339 1990 13 40618 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer